DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20190373

Tubular electrospun scaffolds tested in vivo for tissue engineering

Alan Isaac Valderrama-Treviño, Karen Uriarte-Ruiz, Juan José Granados Romero, Andrés Eliú Castell Rodriguez, Alfredo Maciel-Cerda, Rodrigo Banegaz-Ruiz, Baltazar Barrera-Mera

Abstract


Tissue engineering has been widely used for its great variety of functions. It has been seen as a solution to satisfy the need for vascular substitutes like small diameter vessels, veins, and nerves. One of the most used methods is electrospinning, due to the fact that it allows the use of various polymers, sizes, mandrels and it can adjust the conditions to create personalized scaffolds. For the creation of scaffolds is fundamental to understand the advantages and disadvantages of each polymer, of this, will depend the biodegradability, biocompatibility, porosity, cellular adhesion, and cell proliferation as it is essential to mimic the extracellular matrix and provide structural support for the cells. The aim of this review was to investigate which materials are being used for the creation of tubular scaffolds by electrospinning. Here we selected only in vivo evaluation to demonstrate remodeling of the grafts into native-like tissues, in vitro evaluations had been excluded from this review. We analyze the conditions like speed, distance and voltage and the modifications like growth factors and combinations of natural and synthetic polymers that allow the authors to have a functional scaffold that will suit its purpose.


Keywords


Biomaterials, Dynamic collector, Dynamic electrospinning, Electrospinning, Tissue engineering, Tubular scaffold

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References


Griffith LG, Naughton G. Tissue engineering-current challenges and expanding opportunities. Science. 2002;295(5557):1009-14.

Chan BP, Leong KW. Scaffolding in tissue engineering: general approaches and tissue-specific considerations. Eur Spine J. 2008;17(4):467-79.

X Ma P. Biomimmetic Materials for Tissue Engineering, NIH. 2008;60(2):184-98.

Teo WE, Ramakrishna S. A review on electrospinning design and nanofiber assemblies. Nanotechnol. 2006;17(14):R89-R106.

Buscemi S, Palumbo VD, Maffongelli A, Fazzotta S, Palumbo FS, Licciardi M, et al. Electrospun PHEA-PLA/PCL Scaffold for vascular regeneration: a preliminary in vivo evaluation. Transpl Proc. 2017;49(4):716-21.

Rim NG, Shin CS, Shin H. Current approaches to electrospun nanofibers for tissue engineering. Biomed Mater. 2013;8(1):014102.

Ingavle GC LJ. Advancements in electrospinning of polymeric nanofibrous scaffolds for tissue engineering. Tissue Eng Part B Rev. 2014;20(4):277-93.

Dekker AJ. Electrical Engineering Materials Inc. Prentice Hall. 1959:23-8.

Ercolani E, Del Gaudio C, Bianco A. Vascular tissue engineering of small-diameter blood vessels: reviewing the electrospinning approach. J Tissue Eng Regen Med. 2015;9(8):861-88.

Kruse M, Greuel M, Kreimendahl F, Schneiders T, Bauer B, Gries T, Jockenhoevel S. Electro-spun PLA-PEG-yarns for tissue engineering applications. Biomed Eng/Biomedizinische Technik. 2018 Jun 27;63(3):231-43.

Mrówczyński W, Mugnai D, de Valence S, Tille JC, Khabiri E, Cikirikcioglu M, et al. Porcine carotid artery replacement with biodegradable electrospun poly-e-caprolactone vascular prosthesis. J Vas Surg. 2014 Jan 1;59(1):210-9.

Ye L, Wu X, Duan HY, Geng X, Chen B, Gu YQ, et al. The in vitro and in vivo biocompatibility evaluation of heparin-poly(e-caprolactone) conjugate for vascular tissue engineering scaffolds. J Biomed Mater Res A. 2012;100(12):3251-8.

Chan AHP, Tan RP, Michael PL, Lee BSL, Vanags LZ, Ng MKC, et al. Evaluation of synthetic vascular grafts in a mouse carotid grafting model. PLoS ONE. 2017;12(3):e0174773.

Zhihong W, Yifan W, Jianing W, Chuangnian Z, Hongyu Y, Meifeng Z, et al. Effect of resveratrol on modulation of endothelial cells and macrophages for rapid vascular regeneration from electrospun poly (ε-caprolactone) scaffolds. ACS Appl. Mater. Interfaces. 2017;9(23):19541-51.

Mugnai D, Tille J, Mrówczynski W, Valence S, Montet X, Möller M, et al. Experimental noninferiority trial of synthetic small-caliber biodegradable versus stable vascular grafts. J Thoracic Cardiovas Surg. 2013;146(2):400-7

Jha B, Colello R, Bowman J, Sell S, Lee K, Bigbee J, et al. Two pole air gap electrospinning: Fabrication of highly aligned, three-dimensional scaffolds for nerve reconstruction. Acta Biomaterialia. 2011;7(1):203-15.

Tillman BW, Yazdani SK, Lee SJ, Geary RL, Atala A, Yoo JJ. The in vivo stability of electrospun polycparolactone-collagen scaffolds in vascular reconstruction. Biomaterials. 2009;30(4):583-8.

Yu W, Jiang X, Cai M, Zhao W, Ye D, Zhou D, et al. A novel electrospun nerve conduit enhanced by carbon nanotubes for peripheral nerve regeneration. Nanotechnology. 2014;25(16):165102.

Fotios S, Alexander WJ, Olivia CT, Stephen S, Edmund MG, Sara SU, et al. Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nat Med. 2017;23(8):954-63.

Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, et al. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017;153(4):924-32.

Antonova LV, Sevostyanova VV, Kutikhin AG, Mironov AV, Krivkina EO, Shabaev AR. Vascular endothelial growth factor improves physico-mechanical properties and enhances endothelialization of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (εcaprolactone) small-diameter vascular grafts in vivo. Front Pharmacol. 2016;7:230.

Beigi MH, Ghasemi-Mobarakeh L, Prabhakaran MP, Karbalaie K, Azadeh H, Ramakrishna S, et al. In vivo integration of poly (ε-caprolactone)/gelatin nanofibrous nerve guide seeded with teeth derived steem cells for peripheral nerve regeneration. J Biomed Meter Res A. 2014;102(12):4554-67.

Min Zhou, Wei Qiao, Zhao Liu, Tao Shang, Tong Qiao, Chun Mao, et al. development and in vivo evaluation of small-diameter vascular grafts engineered by outgrowth endothelial cells and electrospun chitosan/poly(ε-caprolactone) nanofibrous scaffolds. Tissue Eng Part A. 2014;20(1-2):79-91.

Cirillo V, Clements B, Guarino V, Bushman J, Kohn J, Ambrosio L. A comparison of the performance of mono-and bi-component electrospun conduits in a rat sciatic model. Biomaterials. 2014;35(32):8970-82.

Zhu L, Wang K, Ma T, Huang L, Xia B, Zhu S, et al. Noncovalent Bonding of RGD and YIGSR to an electrospun poly(ε-caprolactone) conduit through peptide self-assembly to synergistically promote sciatic nerve regeneration in rats. Adv Health Mater. 2017;6(8):1600860.

Chung EJ, Ju HW, Park HJ, Park CH. Three-layered scaffolds for artificial esophagus using poly (ε- caprolactone) nanofibers and silk fibroin: An experimental study in a rat model. J Biomed Mater Res A. 2015;103(6):2057-65.

Cheng S, Jin Y, Wang N, Cao F, Zhang W, Bai W, et al. Self-adjusting, polymeric multilayered roll that can keep the shapes of the blood vessel scaffolds during biodegradation. Advanced Materials. 2017;29(28):1700171.

Soletti L, Nieponice A, Hong Y, Ye S, Stankus J, Wagner W. In vivo performance of phospholipid-coated bioerodable elastomeric graft for small-diameter vascular applications. J Biomed Mater Res A. 2011;96(2):436-48.

Gao Y, Yi T, Shinoka T, Lee YU, Reneker DH, Breuer CK, Becker ML, et al. Pilot Mouse Study of 1 mm Inner Diameter (ID) Vascular Graft Using Electrospun Poly (ester urea) Nanofibers. Materials Views. Adv Health Mater. 2016;5(18):2427-36.

Park YS, Seok C, Hwan Y, Gill K, Woo S, Young H, Jeong H. Functional recovery guided by an electrospun silk fibroin conduit after sciatic nerve injury in rats. J Tissue Engineering Regenerative Med. 2015;9(1):66-76.

Bergmeister H, Grasl C, Walter I, Plasenzotti R, Stoiber M, Schreiber C, et al. Electrospun small-diameter polyurethane vascular grafts: ingrowth and differentiation of vascular-specific host cells. Artif Organs. 2011;36(1):54-61.

Barron M, Blanco E, Aho J, Chakroff J, Johnson J, Cassivi S, et al. Full-thickness oesophageal regeneration in pig using a polyurethane mucosal cell seeded graft. J Tissue Engineering Regenerative Med. 2016;14(1):175-85.

Wang K, Zhang Q, Zhao L, Pan Y, Wang T, Zhi D, et al. Functional modification of electrospun poly (e-caprolactone) vascular grafts with the fusion protein VEGF-HGFI enhanced vascular regeneration. ACS Appl. Mat and Interfaces. 2017;9(13):11415-27.

Kuihua Z, Chunyang W, Cunyi F, Xiumei M. Aligned SF/P(LLA-CL)-blended nanofibers encapsulating nerve growth factor for peripheral nerve regeneration. J Biomed Mater Res A. 2014;102(8):2680-91.

Salehi M, Naseri‐Nosar M, Ebrahimi‐Barough S, Nourani M, Khojasteh A, Hamidieh AA, et al. Sciatic nerve regeneration by transplantation of Schwann cells via erythropoietin controlled‐releasing polylactic acid/multiwalled carbon nanotubes/gelatin nanofibrils neural guidance conduit. J Biomed Mate Res Part B: App Biomat. 2018 May;106(4):1463-76.

Sheng Wang, Xiu M Mo, Bo J Jiang, Cheng J Gao, Hong S Wang, Yu G Zhuang et al. Fabrication of small-diameter vascular scaffolds by i-bonded P(LLA-CL) composite nanofibers to improve graft patency. International Journal of Nanomedicine. 2013; 8(1): 2131-2139.

Huang C, Wang S, Qiu L, Ke Q, Zhai W, Mo X. Heparin loading and pre-endothelialization in enhancing the patency rate of electrospun small-diameter vascular grafts in a canine model. ACS Appl Mater Interfaces. 2013;5:2220-6.

Zhai W, Qiu L-J, Mo X-M, Wang S, Xu Y-F, Peng B, et al. Coaxial electrospinning of P(LLA-CL)/ heparin biodegradable polymer nanofibers: potential vascular graft for substitution of femoral artery. J Biomed Mate Res Part B: App Biomat. 2013;102(1):203.