DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20190013

Association between thrombocyte and neutrophyl count with cutaneous manifestations in children with acute lymphocytic leukemia and acute myelocytic leukemia

Eva Hariani, Sri Wahyuni Purnama, Remenda Siregar

Abstract


Background: Acute leukemia is a hematopoietic stem cell malignant disease, with abnormal proliferation of leukemic and immature cells that suppress the production of normal blood cell and extensively invade peripheral tissues organs including skin. Homeostatic abnormalities that occur in leukemia e.g. thrombocytopenia and neutropenia. Various cutaneous manifestations can be observed in leukemia but the etiology is usually unknown, because many factors are responsible for this cutaneous manifestation. The aim of the present study was to determine association between thrombocyte and neutrophyl count with cutaneous manifestations in children with Acute Lymphocytic Leukemia (ALL) and Acute Myelocytic Leukemia (AML).

Methods: This is an observational analytical cross-sectional study involving 51 children with acute leukemia (ALL and AML) were hospitalized in H. Adam Malik General Hospital Medan during April – September 2018. Interview, dermatology examination and recording thrombocyte and neutrophil count were performed to the subjects. Differences between thrombocyte and neutrophyl count with cutaneous manifestations were analyzed using Mann Whitney test. Association between thrombocyte and neutrophyl count with cutaneous manifestations were analyzed using Kolmogorov Smirnov test.

Results: Children with Acute Leukemia in this study most of them were girls (51.0%), age between 0 - 5years old (39.2%). There were no significant differences between thrombocyte and neutrophyl count with cutaneous manifestations in children with acute leukemia (p value 0.692 and 0.814). There was no significant association between thrombocyte and neutrophyl count with cutaneous manifestations in children with acute leukemia (p value 0.490 and 0.803).

Conclusions: There is no significant association between thrombocyte and neutrophyl count with cutaneous manifestations in children with acute leukemia.


Keywords


Acute leukemia, Cutaneous manifestation, Neutrophyl, Thrombocyte

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References


Permono B, Ugrasena IDG. Leukemia Akut. In:Permono B, Sutaryo, Ugrasena IDG, Windiastuti E, Abdulsalam M, eds. Buku Ajar Hematologi-onkologiAnak. 4th ed. Badan penerbit Ikatan Dokter Anak Indonesia; 2012:236-247.

Deshjer B, Lubbert M. Acute Myeloid Leukemia: Epidemiology and Etiology. In:Estey AH, Faderl SH, Kantarjian HM, ed. Hematologic Malignancies: Acute Leukemias. Springer Berlin Heidelberg New York; 2008:47-55.

Lanzkowsky P. Leukemias. In:Lanzkowsky, editor. Manual of Pediatric Hematology and Oncology. United states Elsevier; 2011:546-77.

Grunwald MR, McDonnel MH, Induru R, Gerber JM. Cutaneous manifestations in leukemia patients. Seminars Oncol. 2016;43(3):359-65.

Geyer JT, Lee S. Acute Leukemia. In:Wekster BB, Schecter GP, Ely SA, eds. Wintrobe’s Atlas of Clinical Hematology. 2nd edition. Wolter Klumer New York; 2018:334-434.

Wagner G, Fennel K, Back W, Schulz A, Sachse MM. Leukemia cutis epidemiology, clinic and differential diagnoses. J German Dermatol Soc. 2012 Jan;10(1):27-37.

Siegel RL, Miller KD, Jemal A. Cancer Statistics 2016. CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30.

Agis H, Weltermann A, Fonatsch C, Haas O, Mitterbauer G, Müllauer L, et al. A comparative study on demographic, hematological, and cytogenetic findings and prognosis in acute myeloid leukemia with and without leukemia cutis. Ann Hematol. 2002 Feb 1;81(2):90-5.

Bansal D, Totadri S. Common hematological disorders in children. Indian J Pediatr. 2014 Jan;81(1):42-50.

Bakhshi S, Padmanjali KS, Arya LS. Infections in childhood acute lymphoblastic leukemia: an analysis of 222 febrile neutropenic episodes. Pediatr Hematol Oncol. 2008 Jan 1;25(5):385-92.

Psaila B, Bussel JB, Frelinger AL, Babula B, Linden MD, Li Y, Barnard MR, et al. Differences in platelet function in patients with acute myeloid leukemia and myelodysplasia compared to equally thrombocytopenic patients with immune thrombocytopenia. J Thromb Haemost. 2011 Nov;9(11):2302-10.

Costello MJ, Canizares O, Montague M, Buncke CM. Cutaneous manifestations of myelogenous leukemia. AMA Arch Dermatol. 1955 May 1;71(5):605-14.

Millot F, Robert A, Bertrand Y, Mechinaud F, Laureys G, Ferster A, et al. Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. Pediatr. 1997 Jul 1;100(1):60-4.