DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20191307

Study of association between the serum lipid profile and age-related macular degeneration in a tertiary care centre of Central UP

Ahmad Husain, Brijesh Singh, Ravi Ranjan, Kalbe Jawad, Ifsa Sami, Vivek Kumar Verma

Abstract


Background: Age-related macular degeneration (ARMD) is the major challenge in the new millennium in the developing countries as the size of elderly population continues to rise due to betterment of medical facilities and increased life expectancy. Lipids are implicated in the pathogenesis of ARMD. The relationship between systemic lipids and ARMD has not been well characterized, especially in rural population. The objective was to investigate the relationship between serum lipids and ARMD in older adults.

Methods: In this case-control study, 300 adults, aged ≥50 years, 150 each among cases and controls were included in the study. Mean lipids values between cases and controls were compared.

Results: Mean age of cases was 62.45±8.472 years and mean age of controls was 61.89±8.51 years. Among 150 cases, 124 (82.66%) cases were of dry ARMD while 26 (17.33%) cases were Wet ARMD. Author found that 38 cases among total cases (25.33%) and 15 individuals (10%) among controls had altered lipid profile. All mean lipid values were higher among cases compare to controls (p>0.05), while the mean of VLDL, TG and TG/HDL were significantly raised showing positive association (p<0.05).

Conclusions: Present study showed that high levels of serum lipid values especially VLDL, TG and TG/HDL positive association with an increased risk for development of ARMD, implying that strategies reducing serum lipid levels may be useful to prevent the development of the disease.


Keywords


Blindness, Dyslipidaemia, Mean lipid profile values, Rural population

Full Text:

PDF

References


Ghafour IM, Allan DO, Foulds WS. Common causes of blindness and visual handicap in the west of Scotland. Brit J Ophthalmol. 1983;67(4):209-13.

Leibowitz HM, Krueger DE, Maunder LR, Milton RC, Kini MM, Kahn HA, et al. The framingham eye study monograph: an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-75. Survey Ophthalmol. 1980;24(Suppl):335-610.

Thylefors B. A global initiative for the elimination of avoidable blindness. Community Eye Heal. 1998;11(25):1.

Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Global Heal. 2014;2(2):e106-16.

Dogra MR, Narang SU, Gupta AM. Epidemiology of age-related macular degeneration. BHM. 2002;44:318-21.

Mullins RF, Russell SR, Anderson DH, Hageman GS. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 2000;14(7):835-46.

Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, et al. Diagnostic criteria for dyslipidemia. J Atherosclerosis Thrombosis. 2013:20(8):655-60.

Hyman L, Schachat AP, He Q, Leske MC. Hypertension, cardiovascular disease, and age-related macular degeneration. Arch Ophthalmol. 2000;118(3):351-8.

Delcourt C, Michel F, Colvez A, Lacroux A, Delage M, Vernet MH. Associations of cardiovascular disease and its risk factors with age-related macular degeneration: the POLA study. Ophthal Epidemiol. 2001;8(4):237-49.

Chakravarthy U, Wong TY, Fletcher A, Piault E, Evans C, Zlateva G, et al. Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol. 2010;10(1):31.

Tomany SC, Wang JJ, van Leeuwen R, Klein R, Mitchell P, Vingerling JR, et al. Risk factors for incident age-related macular degeneration: pooled findings from 3 continents. Ophthalmol. 2004;111(7):1280-7.

Hogg RE, Woodside JV, Gilchrist SE, Graydon R, Fletcher AE, Chan W, et al. Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization. Ophthalmol. 2008;115(6):1046-52.

Friedman DS, O’Colmain BJ, Munoz B, Tomany SC, McCarty C, De Jong PT, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004;122(4):564-72.

Hyman L, Neborsky R. Risk factors for age-related macular degeneration: an update. Current Opinion Ophthalmol. 2002;13(3):171-5.

Topouzis F, Coleman AL, Harris A, Anastasopoulos E, Yu F, Koskosas A, et al. Prevalence of age-related macular degeneration in Greece: the thessaloniki eye study. Am J Ophthalmol. 2006;142(6):1076-9.

Ambreen F, Khan WA, Qureshi N, Qureshi IZ. Assessment of serum lipids in patients with age related macular degeneration from Pakistan. J Pak Med Assoc. 2014;64(6):664-9.

Wang Y, Wang M, Zhang X, Zhang Q, Nie J, Zhang M, et al. The association between the lipids levels in blood and risk of age-related macular degeneration. Nutrients. 2016;8(10):663.

Cougnard-Grégoire A, Delyfer MN, Korobelnik JF, Rougier MB, Le Goff M, Dartigues JF, et al. Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study. PloS One. 2014;9(3):e90973.

Nowak M, Swietochowska E, Marek B, Szapska B, Wielkoszynski T, Kos-Kudla B, et al. Changes in lipid metabolism in women with age-related macular degeneration. Clin Exp Med. 2005;4(4):183-7.

Reynolds R, Rosner B, Seddon JM. Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration. Ophthalmol. 2010;117(10):1989-95.

Davari MH, Gheitasi H, Yaghobi G, Heydari B. Correlation between serum lipids and age-related macular degeneration: a case-control study. J Res Heal Sci. 2013;13(1):98-101.

Belda JS, Quijada AG, Muñoz GR, Rodriguez-Galietero A, Romero FG, Diaz-Llopis M. Are blood lipids a risk factor for age-related macular degeneration?. Arch Soc Esp Oftalmol. 2001;76(1):13-7.

Abalain JH, Carre JL, Leglise D, Robinet A, Legall F, Meskar A, et al. Is age-related macular degeneration associated with serum lipoprotein and lipoparticle levels?. Clin Chim Acta. 2002;326(1-2):97-104.

Leeuwen R, Klaver CC, Vingerling JR, Hofman A, Duijn CM, Stricker BH, et al. Cholesterol and age-related macular degeneration: is there a link?. Am J Ophthalmol. 2004;137(4):750-2.

Leeuwen EM, Emri E, Merle BM, Colijn JM, Kersten E, Cougnard-Gregoire A, et al. A new perspective on lipid research in age-related macular degeneration. Prog Retinal Eye Res. 2018;67:56-86.