Role of diffusion weighted MR imaging in differentiating benign from malignant prostate lesions

Authors

  • Sachin . Department of Radiodiagnosis, Dr. S. N. Medical College, Jodhpur, Rajasthan, India
  • Kirti Chaturvedy Department of Radiodiagnosis, Dr. S. N. Medical College, Jodhpur, Rajasthan, India
  • R. N. Gehlot Department of Radiodiagnosis, Dr. S. N. Medical College, Jodhpur, Rajasthan, India
  • Prateek Sihag Department of Radiodiagnosis, Dr. S. N. Medical College, Jodhpur, Rajasthan, India
  • Suman Kumari Department of Pathology, Dr. S. N. Medical College, Jodhpur, Rajasthan, India
  • Anil Kumar Jangir Department of Radiodiagnosis, Dr. S. N. Medical College, Jodhpur, Rajasthan, India
  • Mohit Jakhar Department of Radiodiagnosis, Dr. S. N. Medical College, Jodhpur, Rajasthan, India
  • Ravindra Purohit Department of Urology, Dr. S. N. Medical College, Jodhpur, Rajasthan, India
  • Tejinder Pal Singh Department of Urology, Dr. S. N. Medical College, Jodhpur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20192525

Keywords:

Apparent diffusion coefficient, Diffusion weighted imaging, Magnetic resonance imaging, Prostate carcinoma

Abstract

Background: The purpose of the study was to determine the diagnostic accuracy of diffusion weighted MR imaging and to propose a cut off ADC value in differentiating benign from malignant prostatic lesions considering histopathology as gold standard.

Methods: It is a descriptive type of observational study done on 40 patients with clinical suspicion of prostate carcinoma and elevated PSA level more than 4ng/ml. The patients underwent Multiparametric prostate MRI and ADC values were calculated using ADC maps.

Results: Of the 40 cases included in the study histopathology revealed a diagnosis of abscess (1), chronic prostatitis (2), BPH with chronic prostatitis (4), BPH (12), and malignancy (21). The mean and standard deviation (SD) of ADC values for the abscess (0.59), CP (0.83+0.16), BPH with CP (0.94+0.22), BPH (1.14+0.14) and malignancy (0.72+0.15) (x10-3mm2/s) were found in our study. The mean ADC value of malignant lesion was lower (0.727+0.149) as compare to benign lesion (1.034+0.216) and this difference was found to be statistically significant with p<0.001. By using ROC curve, ADC cut off value was calculated as 0.92 x 10-3mm2/s and sensitivity, specificity at this cut off value of ADC were 95.24% and 73.68% respectively. The PPV, NPV, diagnostic accuracy of at this cut off value of ADC were 80%, 93.33%, 85% respectively.

Conclusions: Our study shows that DWI with ADC calculation helps in differentiation of Benign from Malignant prostatic lesions with high accuracy and this quantitative analysis should be incorporated in routine MRI evaluation of prostatic lesions

Author Biography

Tejinder Pal Singh, Department of Urology, Dr. S. N. Medical College, Jodhpur, Rajasthan, India

Urology department dr snmc jodhpur rajasthan india

Mch resident

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Published

2019-05-29

How to Cite

., S., Chaturvedy, K., Gehlot, R. N., Sihag, P., Kumari, S., Jangir, A. K., Jakhar, M., Purohit, R., & Singh, T. P. (2019). Role of diffusion weighted MR imaging in differentiating benign from malignant prostate lesions. International Journal of Research in Medical Sciences, 7(6), 2341–2349. https://doi.org/10.18203/2320-6012.ijrms20192525

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Original Research Articles