Study of various reasons for interruption of anti-tubercular treatment in patients of tuberculosis reporting to tertiary care center of west Rajasthan

Authors

  • Gulab S. Yadav Department of Respiratory Medicine, Sawaimansingh Medical College, Jaipur, Rajasthan, India
  • Vinod K. Jangid Department of Respiratory Medicine, Government Medical College, Kota, Rajasthan, India
  • Brij B. Mathur Department of Respiratory Medicine, Government Medical College, Bikaner, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20192542

Keywords:

DOTS, Interruption of treatment, tuberculosis

Abstract

Background: Tuberculosis is a major cause of death in India. Premature cessation of treatment in tuberculosis patient is a leading cause for developing MDR (multidrug resistant tuberculosis) as well as a major threat to control programs. Despite the easy approach and free of cost, availability to antitubercular medicines the interruptions of the treatment are still on a high. So, we analyzed  such various reasons  leading to interrupt the antitubercular treatment.

Methods: Total 150 patients who interrupted the antitubercular treatment, were interviewed with a predesigned questionnaire and the result was analyzed.

Results: Out of total 150 patients 115 (76.7%)  male and 35 (23.3%)  female were interviewed, who were  having  history of antitubercular treatment interruption. Out of 150 patients, 79 (52.7%) patients stopped their treatment because of improvement. Total 25 (16.7%) patients had stopped their treatment because of high cost, 16 (10.7%) due to personal/family reason, 17 (11.4%) patients had stopped their treatment due to nausea/vomiting/anorexia, 5 (3.3%) due to alcoholism/drug or other addiction, 2 (1.3%) patients  had stopped their treatment because they were advised to stop it  by health personnel and long distance travelled to take drugs.

Conclusions: Improvement of symptoms was  the most common reason  in patients who received DOTS treatment and high cost of treatment in patients who received non DOTS treatment. Poor education and socioeconomic status of society are the other reasons for possible treatment interruptions because as soon as the patient improves, they move out to earn their wages to run the family with the unavoidable default from the treatment.

References

World Health Organization‎. Global tuberculosis control: surveillance, planning, financing: WHO report 2008, 2008. Available at: http://www.who.int/iris/handle/10665/43831. Accessed on 7 September 2011.

World Health Organization. Groups at Risk: WHO Report on the Tuberculosis Epidemic 1996. Geneva: 1996. Available at: http://www.who.int/gtb/publications/tbrep_96/index.htm. Accessed on 7 September 2011.

Parikh FR, Naik N, Nadkarni SG, Soonawala SB, Kamat SA, Parikh RM. Genital tuberculosis a major pelvic factor causing infertility in Indian women. Fertil Steril. 1997;767:497-500.

World Health organization. Global tuberculosis control: surveillance, planning, financing. WHO Report 2002. WHO/CDS/TB/2002.295. Geneva, 2002. Available at: http://www.who.int/gtb/publications/globrep02/index.html. Accessed on 10 August 2011.

Fox W. Self administration of medicaments. A review of published work and a study of the problems. Bull Int Union Tuberc. 1961;31:307-31.

Tuberculosis Chemotherapy Centre, Madras. A concurrent comparison of intermittent (twice-weekly) isoniazid plus streptomycin and daily isoniazid plus PAS in the domiciliary treatment of pulmonary tuberculosis. Bull World Health Organ. 1964;31:247-71.

Benerji D, Anderson S. A sociological study of awareness of symptoms among persons with pulmonary tuberculosis. Bull World Health Organ. 1963;29:665-83.

Methers CD, Boerma T Mafat D. Global and regional causes of death. Br Med Bull. 2009;92:7-32.

World Health Organization. Global tuberculosis control: surveillance, planning, financing, WHO report 2007, WHO/HTM/TB/2007. 376, Geneva, 2007. Available at: http://www.who.int/tb/publications/global report/2007/en/index.html.

Prasad BG. Changes proposed in social classification of Indian families. J Ind Med Assoc. 1970;55:198-9.

Lambregts-van Wezenbeek CSB, Veen J. Control of drug resistant tuberculosis. Tubercle Lung Dis. 1995;76:455-8.

Gutpa S, Gupta S, Behera B. Reasons for interruption of ATT as reported by patient with TB admitted in a tertiary care center. Indian J Tuberc. 2011;58:11-7.

Daniel OJ, Oladapo OT, Alausa OK. Default from tuberculosis treatment programme in Sagamu. Nigerial Niger J Med. 2006;15(1):63-7.

Lertmaharit S, Kamol-Ratankul P, Sawert H, Jittimanee S, Wangmanee S. Factors associated with compliance among tuberculosis patients in Thailand. J Med Assoc Thai. 2005;88(4):S149-56.

Malik AS, Ahmad G. Tuberculous; determinants of treatment non-compliance among TB patients, Professional Med J Mar. 2009;16(1):70-75.

SozaPineda NI, Pereira SM, Barreto ML. Dropout from tuberculosis treatment in Nicaragua. Rev Panam Salud Publica. 2005;17(4):271-8.

Jha UM, Satyanarayana S, Dewan PK, Chadha S, Wares F, Sahu S, et al. Risk factors for treatment default among re-treatment tuberculosis patients in India, 2006. PloS One. 2010;5(1):e8873.

Santha T, Garg R, Frieden TR, Chandrasekaran V, Subramani R, et al. Risk factors associated with default, failure and death among tuberculosis patients treated in a DOTS programme in Tiruvallur District, South India 2000. Int J Tuberc Lung Dis. 2002;6(9):780-88.

Castelnuono B. A review of compliance to anti-tuberculosis treatment and risk factors for defaulting treatment in Sub Saharan Africa. Afr Health Sci. 2010;19(4):320-4.

Shargie EB, Lindtiom B. Determinants of treatment adherence among smear-positive pulmonary tuberculosis patients in Southern Ethiopia. PLoS Med. 2007;4(2):e37.

Sophia V, Balasangameswra VH, Jagannatha PS, Saroja VN, Kumar P. Defaults among tuberculosis patients treated under DOTS in Bangalore City: A search for solution. Ind J Tuber. 2003;50:185-95.

Kumar M, Singh JV, Srivastava AK, Verma SK. Factors affecting the non compliance in directly observed short course chemotherapy in Lucknow District. Ind J Commu Med. 2002; XXVII(3).

Jindal SK. Smoking and HIV infection. Lung India. 2005;22:75-6.

Burman WJ, Cohn DL, Rietmeijer CA, Judson FN, Reves RR, Sbarbaro JA. Non compliance with Directly observed therapy for Tuberculosis. Chest. 1997;111(5):1168-73.

Chan-Yeung M, Noertjojo K, Leung CC, Chan SL, Tam CM. Prevalence and predictors of default from tuberculosis treatment in Hong Kong. Hong Kong Med J. 2003;9(4):263-8.

Oliveira VL, da Cunha AJ, Alves R. Tuberculosis treatment default among Brazilian children. Int J Tuberc Lung Dis. 2006;10(8):864-9.

Tekle B, Mariam DH, Ali A. Defaulting from DOTS and its determinants in three districts of Arsi Zone in Ethiopia. Int J Tuberc Lung Dis. 2002;6(7):573-9.

Chee CB, Boudville IC, Chan SP, Zee YK, Wang YT. Patient and disease characteristics, and outcome of treatment defaulters from the Singapore TB control unit-a one-year retrospective survey. Int J Tuberc Lung Dis. 2000;4(6):496-503.

Tissera WAA. Non-compliance with Anti-tuberculous treatment at Colombo Chest Clinic. NTI Bulletin. 2003;39:5-9.

Jaggarajamma K, Sudha G, Chandrasekaran V, Nirupa C, Thomas A, Santha T, et al. Reasons for non-compliance among patients treated under Revised National Tuberculosis Control Programme (RNTCP), Tiruvallur district, south India. Indian J Tuberc. 2007;54(3):130-5.

Jakubowiak WM, Bogorodskaya EM, Borisov SE, Danilova ID, Lomakina OB, Kourbatova EV. Social support and incentives programme for patients with tuberculosis: experience from the Russian Federation. Int J Tuberc Lung Dis. 2007;11(11):1210-5.

Chaterjee C, Banerjee B, Dutt D, Pati RR, Mullick AK. A comparative evaluation of factors and reasons for defaulting in tuberculosis treatment in the states of West Bengal, Jharkhand and Arunachal Pradesh. Indian J Tuberc. 2003;50:17-21.

Pathak SH. Proceedings of 20th tuberculosis and chest diseases workers conference. Indian J Tuber. 1965;12:217.

Mishra P, Hansen EH, Sabroe S, Kafle KK. Adherence is associated with the quality of professional patient interactions in Directly Observed Treatment Short Course, DOTS. Patients Educ Coun. 2006;63(1-2):29-37.

Hill PC, Stevens W, Hill S, Bah J, Donkor SA, Jallow A, Lienhardt C. Risk factors for defaulting from tuberculosis treatment: a prospective cohort study of 301 cases in the Gambia. Int J Tuberc Lung Dis. 2005;9(12):1349-54.

Downloads

Published

2019-05-29

How to Cite

Yadav, G. S., Jangid, V. K., & Mathur, B. B. (2019). Study of various reasons for interruption of anti-tubercular treatment in patients of tuberculosis reporting to tertiary care center of west Rajasthan. International Journal of Research in Medical Sciences, 7(6), 2220–2226. https://doi.org/10.18203/2320-6012.ijrms20192542

Issue

Section

Original Research Articles