Malignant nodular hidradenoma-inguinal region clinically masquerading as squamous cell carcinoma: a case report
DOI:
https://doi.org/10.18203/2320-6012.ijrms20192933Keywords:
Hidradenocarcinoma, Malignant nodular Hidradenoma, Sweat gland tumourAbstract
Malignant Nodular hidradenoma is an extremely rare aggressive tumour originating from eccrine sweat glands with an incidence of <.001%. So far less than 80 cases have been reported in the literature. It’s known for its local recurrence (50%) and metastasis (60%) and hence early diagnosis and radical treatment is mandatory. But differentiating it from its benign counterparts and other skin tumour mimics is challenging, due to its histopathological similarity & lack of diagnostic immunomarkers. Authors report a case of 65-year-old female who presented with a short 4-month history of rapidly growing ulceroproliferative growth in the right inguinal region with bilateral inguinal node enlargement, associated with pain and discharge. Wedge biopsy of left inguinal lymph node showed malignant cutaneous adnexal tumour deposits, which after excision was typed as malignant nodular hidradenoma. It was confirmed with immunohistochemistry. Patient presented with recurrence 8 months after excision.
References
Keasbey LE, Hadley GG. Clear‐cell hidradenoma. Report of three cases with widespread metastases. Cancer. 1954;7(5):934-52.
Mehregan AH, Hashimoto K, Rahbari H. Eccrine adenocarcinoma: a clinicopathologic study of 35 cases. Arch Dermatol. 1983;119(2):104-14.
Obaidat NA, Alsaad KO, Ghazarian D. Skin adnexal neoplasms-part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol. 2007;60(2):145-59.
Cohen M, Cassarino DS, Shih HB, Abemayor E, St John M. Apocrine hidradenocarcinoma of the scalp: a classification conundrum. Head Neck Pathol. 2009;3(1):42-6.
Stewart CL. Tumours of the epidermal appendages. In: Elder DE, Elenitsas R, Rosenbach M, Murphy GF, Rubin AI, Xu X, eds. Histopathology of the skin. 11th Ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014: 2128-2134.
Gauerke S, Driscoll JJ. Hidradenocarcinomas: a brief review and future directions. Arch Pathol Laboratory Med. 2010;134(5):781-5.
Kazakov DV, Ivan D, Kutzner H, Spagnolo DV, Grossmann P, Vanecek T, et al. Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t (11;19) translocation. Am J Dermato Pathol. 2009;31(3):236-47.
Stefanato CM, Ferrara G, Chaudhry IH, Pineda CG, Waschkowski G, Rose C, et al. Clear cell nodular hidradenoma involving the lymphatic system: a tumor of uncertain malignant potential or a novel example of metastasizing benign tumor?. Am J Surg Pathol. 2012;36(12):1835-40.
Nazarian RM, Kapur P, Rakheja D, Piris A, Duncan LM, Mihm MC, et al. Atypical and malignant hidradenomas: a histological and immune-histochemical study. Mod Pathol. 2009;22(4):600-10.
Ko CJ, Cochran AJ, Eng W, et al. Hidradenocarcinoma: a histological and immunohistochemical study. J Cutan Pathol. 2006;33(11):726-30.
Garcia-Bonafe MM, Campins MM, Redecilla PH. Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol. 2009;53(5):576-80.
Thomas CJ, Wood GC, Marks VJ. Mohs micrographic surgery in the treatment of rare aggressive cutaneous tumors: the Geisinger experience. Dermatol Surg. 2007;33(3):333-9.
Ohta M, Hiramoto M, Fujii M, Togo T. Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. Dermatol Surg. 2004;30(9):1265-8.
Wong TY, Suster S, Nogita T, Duncan LM, Dickersin RG, Mihm Jr MC. Clear cell eccrine carcinomas of the skin. A clinicopathologic study of nine patients. Cancer. 1994;73(6):1631-43.
Jinnah AH, Emory CL, Mai NH, Bergman S, Salih ZT. Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis. Diagn Cytopathol. 2016;44(5):438-41.
Balaban K, Sedele M, Sayiner A. Malignant nodular hidradenoma of the scalp: A case report. J Clin Anal Med. 2017;8(3):240-1.
Orsaria M, Mariuzzi L. Recurrent eccrine hidradenoma of the breast in a male patient: problems in differential diagnosis. Dermatol Online/Nasza Dermatol Online. 2013;4(2):215-7.
Nazerali RS, Tan C, Fung MA, Chen SL, Wong MS. Hidradenocarcinoma of the finger. Ann plast Surg. 2013;70(4):423-6.
Khan SA, Ali AA, Ferdousi S, Riyad M, Mahmud AA. Malignant Nodular Hidradenoma: Isolated Case Report and Review of Literature. J Bangladesh Coll Physicians Surg. 2016;34(2):100-3.
Wong TY, Suster S, Nogita T, Duncan LM, Dickersin RG, Mihm Jr MC. Clear cell eccrine carcinomas of the skin. A clinicopathologic study of nine patients. Cancer. 1994;73(6):1631-43.
