Clinical comparison of different cardiovascular risk scores for cardiovascular risk prediction in Indian patients

Authors

  • Azad Abdul Salam Department of Cardiology, Jubilee Mission Medical College, Kerala, India
  • T. Govindan Unni Department of Cardiology, Jubilee Mission Medical College, Kerala, India
  • Bino Benjamin Department of Cardiology, Jubilee Mission Medical College, Kerala, India
  • Prasanna C. K. Department of Cardiology, Jubilee Mission Medical College, Kerala, India
  • Manoj Ravi Department of Cardiology, Jubilee Mission Medical College, Kerala, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20192916

Keywords:

Cardiovascular risk calculators, Myocardial infarction, Primary prevention

Abstract

Background: Cardiovascular diseases (CVD) are the main cause of mortality and disability in India. Early and sustained exposure to behavioral risk factors leads to development of CVD. The present study was conducted to compare different cardiovascular calculators for CVD risk assessment models in young Indian patients presenting with myocardial infarction.

Methods: This study included 85 patients with myocardial infarction (MI). Their predicted 10-year risk of CVD was calculated using three clinically most relevant risk assessment models viz. Framingham Risk score (RiskFRS), American College of Cardiology/American Heart Association (RiskACC/AHA) and the 3rd Joint British Societies risk calculator (RiskJBS).

Results: RiskFRS recognized the highest number of patients (15.4%) at high CVD risk while RiskACC/AHA and RiskJBS calculators provided inferior risk assessment but statistically significant relationship. RiskFRS and RiskACC/AHA (Pearson's r 0.870, p<0.001).

Conclusions: RiskFRS seems to be as most useful CVD risk assessment model in young Indian patients. RiskFRS is likely to identify the number of patients at ‘high-risk’ as compared to RiskJBS and RiskACC/AHA.

References

Gaziano TA, Abrahams-Gessel S, Alam S, Alam D, Ali M, Bloomfield G, et al. Comparison of Nonblood-based and blood-based total CV risk scores in global populations. Global Heart. 2016;11(1):37-46.

Garg N, Muduli SK, Kapoor A, Tewari S, Kumar S, Khanna R, et al. Comparison of different cardiovascular risk score calculators for cardiovascular risk prediction and guideline recommended statin uses. Indian Heart J. 2017;69(4):458-63.

Bansal M, Kasliwal RR, Trehan N. Comparative accuracy of different risk scores in assessing cardiovascular risk in Indians: a study in patients with first myocardial infarction. Indian Heart J. 2014;66(6):580-6.

D'Agostino RB, Sr., Pencina MJ, Massaro JM, Coady S. Cardiovascular Disease Risk Assessment: Insights from Framingham. Glob Heart. 2013;8(1):11-23.

Goff DC, Lloyd-Jones DM, Bennett G, Coady S, D’agostino RB, Gibbons R, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63(25 Part B):2935-59.

Board JB. Joint British Societies’ consensus recommendations for the prevention of cardiovascular disease (JBS3). Heart. 2014 Apr 1;100(Suppl 2):ii1-67.

Kanjilal S, Rao V, Mukherjee M, Natesha B, Renuka K, Sibi K, et al. Application of cardiovascular disease risk prediction models and the relevance of novel biomarkers to risk stratification in Asian Indians. Vascular Health Risk Management. 2008;4(1):199.

Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth universal definition of myocardial infarction (2018). J Ame Coll Cardiol. 2018:25285.

O'gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK, De Lemos JA, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Ame Coll Cardiol. 2013;61(4):485-510.

Jneid H, Anderson JL, Wright RS, Adams CD, Bridges CR, Casey DE, et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non–ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Ame Coll Cardiol. 2012;60(7):645-81.

Nelson DE, Powell-Griner E, Town M, Kovar MG. A comparison of national estimates from the national health interview survey and the behavioral risk factor surveillance system. Ame J Pub Heal. 2003;93(8):1335-41.

Garg N, Muduli SK, Kapoor A, Tewari S, Kumar S, Khanna R, Goel PK. Comparison of different cardiovascular risk score calculators for cardiovascular risk prediction and guideline recommended statin uses. Indian Heart J. 2017 Jul 1;69(4):458-63.

Artigao-Rodenas LM, Carbayo-Herencia JA, Divisón-Garrote JA, Gil-Guillén VF, Massó-Orozco J, Simarro-Rueda M, et al. Framingham Risk Score for Prediction of Cardiovascular Diseases: A Population-Based Study from Southern Europe. PLoS One. 2013;8(9).

Bansal M, Shrivastava S, Mehrotra R, Agarwal V, Kasliwal RR. Low Framingham risk score despite high prevalence of metabolic syndrome in asymptomatic North-Indian population. J Associa Phys India. 2009;57:17-22.

Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Ame Coll Cardiol. 2014;63(25 Pt B):2889-934.

Ridker PM, Cook NR. Statins: new American guidelines for prevention of cardiovascular disease. Lancet (London, England). 2013;382(9907):1762-5.

Akosah KO, Schaper A, Cogbill C, Schoenfeld P. Preventing myocardial infarction in the young adult in the first place: how do the national cholesterol education panel iii guidelines perform? J Am Coll Cardiol. 2003;41(9):1475-9.

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Published

2019-06-28

How to Cite

Salam, A. A., Unni, T. G., Benjamin, B., K., P. C., & Ravi, M. (2019). Clinical comparison of different cardiovascular risk scores for cardiovascular risk prediction in Indian patients. International Journal of Research in Medical Sciences, 7(7), 2770–2774. https://doi.org/10.18203/2320-6012.ijrms20192916

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Section

Original Research Articles