A comparative study on hematological parameters among the social and problem drinkers admitted in a tertiary care rehabilitation centre
DOI:
https://doi.org/10.18203/2320-6012.ijrms20193381Keywords:
Hemoglobin, Mean corpuscular volume, Problem drinkers, Red blood cell, Social drinkersAbstract
Background: Alcoholism is a broad form for problems with alcohol and is generally used to mean compulsive and uncontrolled consumption of alcoholic beverages, usually to the determinant of drinker’s health, personal relationships and social standing. It is medically considered a disease, specifically an addictive illness. Alcohol has numerous adverse effects on the various types of blood cells and their functions. This study aimed to evaluate the hematological changes in alcoholic patients admitted in tertiary care hospital.
Methods: The blood samples were collected from alcoholics admitted in a psychiatric and rehabilitation centre and the samples were processed in hematology laboratory in a tertiary care hospital. The hematological parameters (CBC) except ESR, were performed by using fully automated blood cell counters. The change in alcoholics was studied under two categories-social drinkers and problem drinkers. The results of these parameters were compared with age and sex matched normal population.
Results: Total 200 cases included in which 110 were abstainers and 90 were alcoholics. Among alcoholics 67% were problem drinkers and 33% were social drinkers. The mean values of Hb, RBC and MCV in social drinkers were 11.1 g/dl, 3.1 million cells /μl and 100.5 fl, in problem drinkers were 9.8 g/dl, 2.89 million cells /μl and 105.5 fl, and in control population were 14.8 g/dl, 4.8 million cells / μl and 93 fl respectively.
Conclusions: The study shown that parameters were changed in both social drinkers and problem drinkers. But predominant changes were observed in problem drinkers. The presence of elevated MCV and decreased RBC and Hb are suggestive of megaloblastic changes.
References
Monti PM, Teyyaw TO’L, Borsari B. Drinking among young adults: screening, brief interventions and outcome. Alcohol Res Heal. 2005;28(4):236-44.
Moyer A, Finney JW, Swearingen CE, Vergun P. Brief interventions for alcohol problems: a meta‐analytic review of controlled investigations in treatment‐seeking and non‐treatment‐seeking populations. Addict. 2002;97(3):279-92.
Matzger H, Delucchi K, Weisner C, Ammon L. Does marital status predict long-term drinking? Five-year observations of dependent and problem drinkers. J Studies Alcohol. 2004;65(2):255-65.
Wang JC, Hinrichs AL, Stock H, Budde J, Allen R, Bertelsen S, et al. Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. Human Mol Gen. 2004;13(17):1903-11.
Bullers S, Cooper ML, Russell M. Social network drinking and adult alcohol involvement: a longitudinal exploration of the direction of influence. Addict Behav. 2001;26(2):181-99.
Ballard HS. The hematological complications of alcoholism. Alcohol Heal Res World. 1997;21:42-52.
Duarte AP, Dong QS, Young J, Abi-Younes S, Myers AK. Inhibition of platelet aggregation in whole blood by alcohol. Thrombos Res. 1995;78(2):107-15.
Deitrich RA, Erwin VG. Pharmacological effects of ethanol on the nervous system. Boca Raton, FL, CRC Press. 1996;17:383-408.
Sanft HJ, Schulz K. Hematological changes following chronic alcoholism. Folia Haem Int Mag Klin Morpho Blutforsch. 1983;110(4):540-563.
Herman AI, Philbeck JW, Vasilopoulos NL, Depetrillo PB. Serotonin transporter promoter polymorphism and differences in alcohol consumption behaviour in a college student population. Alcohol Alcoholism. 2003;38(5):446-9.
Seppä K, Heinilä K, Sillanaukee P, Saarni M. Evaluation of macrocytosis by general practitioners. J Studies Alcohol. 1996;57(1):97-100.
Thoma EL, Bitri S, Mucaj K, Tahiri A, Pano I. Changes of some blood count variables in correlation with the time of alcohol abuse. J Addict Res Ther. 2015;6:2.
Charles AT, Everton E, Osaro E. Evaluation of hematological parameters among alcoholics in Port Harcourt Nigeria. Brit J Med Heal Sci. 2015;5:32-44.
Das SK, Mukherjee S, Vasudevan DM, Balakrishnan V. Comparison of haematological parameters in patients with non-alcoholic fatty liver disease and alcoholic liver disease. Singapore Med J. 2011;52(3):175-81.
Laufer EM, Hartman TJ, Baer DJ, Gunter EW, Dorgan JF, Campbell WS, et al. Effects of moderate alcohol consumption on folate and vitamin B 12 status in postmenopausal women. Euro J Clin Nutri. 2004;58(11):1518.
Elanchezhian Y, Mayilsamy S, Radhakrishnan S. Comparison of haematological parameters between alcoholics and non-alcoholics. Int J Res Med Sci. 2017;5:5041-7.
