The research progress on the mechanism of adenosine A1 receptor-mediated calcitonin gene-related peptide to relieve migraine

Authors

  • Zheng Hai Fei Department of Medicine, Affiliated hospital of Binzhou Medical University, Binzhou, Shandong, China
  • Song Wei Wei Department of Medicine, Affiliated hospital of Binzhou Medical University, Binzhou, Shandong, China
  • Chen Jin Bo Department of Medicine, Affiliated hospital of Binzhou Medical University, Binzhou, Shandong, China
  • Zhang Ying Department of Medicine, Affiliated hospital of Binzhou Medical University, Binzhou, Shandong, China

DOI:

https://doi.org/10.18203/2320-6012.ijrms20195016

Keywords:

Adenosine A1 receptor, Analgesia, Calcitonin gene-related peptide, Migraine

Abstract

Currently, the pathogenesis of migraine is unclear. The trigeminal vascular reflex theory is the dominant pathogenesis theory, and its core parts are neurogenic inflammation and pain sensitisation. Calcitonin gene related peptide (CGRP) is the most powerful vasodilating peptide in brain circulation. It is also a marker of trigeminal nerve microvascular activation that plays a synergistic role in the pathogenesis of migraine. Adenosine A1 receptor (A1R) can inhibit the release of CGRP in the trigeminal nerve vascular system to alleviate migraine by mediating adenosine. This review summarises the progress of research on the alleviation of migraine by using A1R-mediated CGRP.

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Published

2019-10-24

How to Cite

Fei, Z. H., Wei, S. W., Bo, C. J., & Ying, Z. (2019). The research progress on the mechanism of adenosine A1 receptor-mediated calcitonin gene-related peptide to relieve migraine. International Journal of Research in Medical Sciences, 7(11), 4429–4432. https://doi.org/10.18203/2320-6012.ijrms20195016

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Section

Review Articles