Sporadic ovarian sex cord-stromal tumor with annular tubules: a rare case report
DOI:
https://doi.org/10.18203/2320-6012.ijrms20193955Keywords:
Annular tubules, Inhibin, Sex cord stromal tumors, Sex cord tumors with annular tubulesAbstract
Ovarian sex cord stromal tumor with annular tubules (SCTAT) is a distinctive, rare subtype of sex cord stromal tumor of the ovary, predominant component of which has morphological features intermediate between that of granulosa cell and sertoli cell. The majority of ovarian SCTAT are benign. So far, malignant behavior in SCTAT has been reported only in sporadic cases. We have presented a case of SCTAT in a 40 year old lady with no association of Peutz-Jegher (P-J) syndrome. The patient’s chief complaints were post-menopausal bleeding for 1 year on and off along with menorrhagia. MRI abdomen was suggestive of intensely enhancing solid tissue mass lesion in the right adnexa, features suggestive of ovarian mass. Panhysterectomy was done. Grossly uterus and left adnexa appeared to be normal. Right ovary showed mass measuring 17x11x9cm3 in size, on cut section, solid, homogenous lobulated, yellowish areas identified. Microscopic and Immunohistochemistry findings confirmed the diagnosis of sex cord stromal tumor with annular tubules of granulosa cell type. PAS stain supported the diagnosis.
References
Scully RE. Sex cord tumor with annular tubules: a distinctive ovarian tumor of the Peutz-Jeghers syndrome. Cancer. 1970;25(5):1107-212.
Demir H, Öztürk TK, Calay Z, İlvan Ş, Demirkıran F. Sex Cord-Stromal Tumor with Annular Tubules of the Ovary Erciyes Med J. 2016;38(3):122-4.
Zaloudek CJ, Mooney EE, Staats PN, Young RH. Sex cord-stromal tumours in WHO classification of tumours of female reproductive organs. Lyon: International Agency for Research on Cancer; 4th Edi;2014:53.
Stacey E Mills et al; Sternberg's diagnostic surgical pathology; vol2, 6th ed, chapter 55; wolters kluwer health; 2015: 2588-90
Nosov V, Park S, Rao J, Memarzadeh S. Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report. Fertil steril. 2009;92(4):1497-e5.
Bembde AS, Manzoor I, Somani S, Mulay SS. Ovarian Sex Cord Stromal Tumor with Annular Tubules-A Case Report & Review of Literature. Int J Health Sci Res. 2014;4(1):192-7.
yuqing Wang, Rui Dong, Yangyang Ma, Lian Chen, Shan Zheng et al. Histological changes of non-peutz-jegher syndrome associated with ovarian sex cord tumor with annular tubules in childhood. Int J Clin Exp Pathol. 2017;10(8):8470-8.
Momin YA, Kulkarni MP, Pandav AB, Sulhyan KR. Non Peutz-Jegher syndrome associated malignant sex cord stromal tumor with annular tubules. International Journal of Applied and Basic Medical Research. 2013 Jul;3(2):126.
Archana S. Bembde, Irmeen Manzoor, Shweta Somani, Smita S Mulay. Ovarian Sex Cord Stromal Tumor with Annular Tubules -A Case Report & Review of Literature. IJHSR. 2014;4(1):2249-9571.