Correlation of serum androgen and gonadotropin with anti-mullerian hormone in polycystic ovarian syndrome in Eastern Indian population

Authors

  • Somnath Singh Raghuvanshi Department of Endocrinology and Metabolism, Medical College, Kolkata, West Bengal, India
  • Anirban Sinha Department of Endocrinology and Metabolism, Medical College, Kolkata, West Bengal, India
  • Animesh Maiti Department of Endocrinology and Metabolism, Medical College, Kolkata, West Bengal, India
  • Partha Pratim Chakraborty Department of Endocrinology and Metabolism, Medical College, Kolkata, West Bengal, India
  • Asish Kumar Basu Department of Endocrinology and Metabolism, Medical College, Kolkata, West Bengal, India
  • Sayan Ghosh Department of Endocrinology and Metabolism, Medical College, Kolkata, West Bengal, India
  • Saurav Shishir Agrawal Department of Endocrinology and Metabolism, Medical College, Kolkata, West Bengal, India
  • Chhavi Agrawal Department of Endocrinology and Metabolism, Medical College, Kolkata, West Bengal, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20195918

Keywords:

Androstenedione, Anti-mullerian hormone, Dehydroepiandrosterone, Follicle stimulating hormone, Luteinising hormone

Abstract

Background: Ovarian steroidogenesis requires gonadotropin stimulation, Luteinizing Hormone (LH) is a key factor in the hyperandrogenaemia of the polycystic ovary syndrome. Progesterone is the primary regulator of Gonadotropin-Releasing Hormone (GnRH) pulse frequency; however, in the polycystic ovary syndrome, the GnRH pulse generator is relatively resistant to the negative feedback effects of progesterone.  Study aims to evaluate the association of Anti-mullerian hormone with serum androgen and gonadotropin level in adolescents and young women of Polycystic Ovary Syndrome (PCOS).

Methods: This was a single centre observational Cross-sectional study carried out in the department of Endocrinology and metabolism, Medical College, Kolkata from March 2017 to January 2019. Total number of study subjects were 207 out of which 138 were cases.

Results: The AMH had strong positive correlation with serum testosterone in both case and control groups (r 0.542, p<0.001 and r 0.57, p<0.001) respectively .After the adjustment of age and BMI , the AMH moderately positive  but extremely significant correlation with serum testosterone as compare to control.

Conclusions: Hyperandrogenaemia and higher ratio of LH and FSH associated with higher serum AMH level is associated with the higher serum AMH in polycystic ovarian syndrome.

References

McCartney CR, Marshall JC. Polycystic ovary syndrome. N Engl J Med. 2016 Jul 7;375(1):54-64.

Eagleson CA, Gingrich MB, Pastor CL, Arora TK, Burt CM, Evans WS, et al. Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J Clini Endocrinol Metab. 2000 Nov 1;85(11):4047-52.

Nelson VL, Legro RS, Strauss III JF, McAllister JM. Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. Mole Endocrinol. 1999 Jun 1;13(6):946-57.

Piltonen T, Morin-Papunen L, Koivunen R, Perheentupa A, Ruokonen A, Tapanainen JS. Serum anti-Müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome. Human Repro. 2005 Mar 31;20(7):1820-6.

Pinola P, Morin-Papunen LC, Bloigu A, Puukka K, Ruokonen A, Järvelin MR, et al. Anti-Müllerian hormone: correlation with testosterone and oligo-or amenorrhoea in female adolescence in a population-based cohort study. Human Repro. 2014 Jul 23;29(10):2317-25.

Eldar-Geva T, Margalioth EJ, Gal M, Ben-Chetrit A, Algur N, Zylber-Haran E, et al. Serum anti-Mullerian hormone levels during controlled ovarian hyperstimulation in women with polycystic ovaries with and without hyperandrogenism. Human Repro. 2005 Mar 31;20(7):1814-9.

Durlinger AL, Visser JA, Themmen AP. Regulation of ovarian function: the role of anti-Mullerian hormone. Reproduction. 2002;124:601-9.

Song DK, Oh JY, Lee H, Sung YA. Anti-Müllerian hormone in PCOS women Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cut-off value. Korean J Int Med. 2017 Jul;32(4):690-8.

Laven JS, Mulders AG, Visser JA, Themmen AP, de Jong FH, Fauser BC. Anti-Mullerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age. J Clin Endocrinol Metab. 2004 Jan 1;89(1):318-23.

Piouka A, Farmakiotis D, Katsikis I, Macut D, Gerou S, Panidis D. Anti-Mullerian hormone levels reflect severity of PCOS but are negatively influenced by obesity: relationship with increased luteinizing hormone levels. Am J Physiol-Endocrinol Metab. 2009 Feb;296(2):E238-43.

Fanchin R, Schonäuer LM, Righini C, Guibourdenche J, Frydman R, Taieb J. Serum anti‐Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Human Repro. 2003 Feb 1;18(2):323-7.

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Published

2019-12-25

How to Cite

Raghuvanshi, S. S., Sinha, A., Maiti, A., Chakraborty, P. P., Basu, A. K., Ghosh, S., Agrawal, S. S., & Agrawal, C. (2019). Correlation of serum androgen and gonadotropin with anti-mullerian hormone in polycystic ovarian syndrome in Eastern Indian population. International Journal of Research in Medical Sciences, 8(1), 256–259. https://doi.org/10.18203/2320-6012.ijrms20195918

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Original Research Articles