Study of serum uric acid in liver cirrhosis and its correlation with Child Turcotte Pugh, MELD and UKELD score


  • B. C. Prakash Department of General Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India
  • Sanjana K. Rai Department of General Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India



Child Turcotte Pugh score, Liver cirrhosis, Model for end stage liver disease, Prothrombin time/ International normalized ratio, United Kingdom model for end stage liver disease


Background: Liver cirrhosis is one of the most common causes of morbidity and mortality. The availability of liver transplant has stressed on the need for accurate prognostication. Various scoring systems have been developed for the same and studies have been conducted to find the correlation of various biochemical parameters with these.

Methods: This is a cross sectional study conducted on 100 patients with stigmata of liver cell failure on clinical examination and substantiated by imaging. Serum Uric acid and other biochemical parameters were determined. Child Turcotte Pugh Score, Model for End Stage Liver Disease (MELD) score, United Kingdom Model for End Stage Liver Disease (UKELD) score was calculated and the correlation obtained.

Results: The study showed significant, positive correlation between uric acid level and CTP, MELD and UKELD score. The study also showed the positive correlation of serum uric acid with various biochemical parameters such as total bilirubin, Prothrombin time/ International Normalized Ratio (PT/INR) and serum creatinine and negative correlation with serum albumin, with a significant p value. The mean serum uric acid was found to be 4.79(4.79± 2.0)

Conclusions: The study showed a correlation between serum uric acid and the various available scoring systems such as CTP score, MELD and UKELD score. Hence serum uric acid can be used as an alternative prognostic parameter in predicting the severity and prognosis of cirrhosis of liver.


Xiao J, Wang F, Wong NK, He J, Zhang R, Sun R, et al. Global liver disease burdens and research trends: analysis from a china perspective. J Hepatol, 2019;71(1):212-21.

Wong MC, Huang J. The growing burden of liver cirrhosis: implications for preventive measures. Hepatol Inter. May 2018;12(3):201-3.

Dooley J, Lok A, Burroughs A, Heathcote J. Sherlock’s Diseases of Liver and Biliary system. 12th ed. UK: Wiley Blackwell, A John Wiley and Sons, Ltd; 2011;11(5):506.

Upadhyay R. Alcoholic Liver Disease. In: Munjal Y P, Sharma S K, eds. API Textbook of Medicine. 9th ed. New Delhi: Jaypee Brothers; 2012: 873-882.

Burns CM, Wartmann RL. Disorders of purine and pyrimidine metabolism. Harrison's principles of internal medicine. 18th eds. New York: McGraw Hill; 2012:3181-7.

Kono H, Chen CJ, Ontiveros F, Rock KL. Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest. 2010;120(6):1939-49.

Paul R, Chakravarti HN, Mandal SK, Chatterjee S, Choudhury PS. Study of serum uric acid in chronic liver disease and its relation with other parameters. Int Res J Pharm. 2013;4(7):162-5.

Kanemitsu H, Tamura A, Sano K, Iwamoto T, Yoshiura M, Iriyama K. Changes of uric acid level in rat brain after focal ischemia. J Neurochem. 1986;46(3):851-3.

Bergheim I, McClain CJ, Arteel GE. Treatment of alcoholic liver disease. Dig Dis. 2005;23(3-4):275-84.

Kim WR, Biggins SW, Kremers WK, Wiesner RH, Kamath PS, Benson JT, et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. New Engl J Med. 2008;359(10):1018-26.

Jain D, Aggarwal HK, Rao A, Dahiya S, Singla S. Hematological Spectrum in Patients with Alcoholic Liver Cirrhosis: A Model of End Stage Liver Disease Score Based Approach. Intern J Advan Med. 2016;3(2):234.

Barber KM, Pioli SE, Blackwell JE, Collett D, Neuberger JM, Gimson AE. Development of a UK score for patients with end-stage liver disease. Hepatol. 2007;46(4):510-10.

Afzali A, Weiss NS, Boyko EJ, Ioannou GN. Association between serum uric acid level and chronic liver disease in the United States. Hepatol. 2010;52(2):578-89.

Lee YJ, Lee HR, Lee JH, Shin YH, Shim JY. Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. Clin Chem Laborat Med. 2010;48(2):175-80.

Evangelopoulos AA, Vallianou NG, Panagiotakos DB, Georgiou AT, Zacharias GA, Vogiatzakis ED, et al. The Association Between Uric Acid and Hepatic Function Markers with the Metabolic Syndrome in Middle-aged, Overweight, and Obese People. Endocrinol. 2010;20(6):312-5.




How to Cite

Prakash, B. C., & Rai, S. K. (2020). Study of serum uric acid in liver cirrhosis and its correlation with Child Turcotte Pugh, MELD and UKELD score. International Journal of Research in Medical Sciences, 8(2), 450–454.



Original Research Articles