A comparative study on concurrent chemoradiation using cisplatin versus carboplatin in the management of locoregionally advanced non-small cell lung cancer

Authors

  • Nithin D. Raj Department of Radiation Oncology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Sobita D. Yumkhaibam Department of Radiation Oncology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Srigopal Mohanty Department of Radiation Oncology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • James L. Chongthu Department of Radiation Oncology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Jaichand S. Laishram Department of Radiation Oncology, Regional Institute of Medical Sciences, Imphal, Manipur, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20200773

Keywords:

Carboplatin, Cisplatin, Concurrent chemoradiation, Locoregionally advanced non-small cell lung cancer

Abstract

Background: Concurrent chemoradiation is considered the standard care for locoregionally advanced non-small cell lung cancer. This study aimed to compare the treatment response, progression free survival and treatment toxicities between cisplatin and carboplatin based concurrent chemoradiation.

Methods: Between October 2015 and September 2017, 60 eligible patients were enrolled and divided into two arms of 30 patients each. Arm A received EBRT to chest (60Gy/30 fractions) with concurrent weekly Injection Cisplatin 35mg/m2. Arm B received EBRT to chest (60Gy/30 fractions) with concurrent weekly Injection Carboplatin at a dose of AUC-2. Early treatment response was assessed at 1 month and late treatment response at 6 months after completion of radiation using RECIST criteria. Treatment toxicities was assessed using RTOG toxicity criteria. All statistical analysis was carried out using SPSS version 21.

Results: Most patients were in the age range of 61-70 years. Mean age of presentation was 67.53±11.038 years in Arm A and 66.03±12.794 years in Arm B. Median follow up was 16 months for both arms. Response rate of was slightly better in Arm A (73.3% versus 60%). 1 year PFS rate was 53.33% in Arm A and 36.67% in Arm B. Median time to progression was better in Arm A (11 months vs 10 months). Toxicities were almost comparable in both the arms.

Conclusions: Use of carboplatin in combination with radiation therapy is comparable to cisplatin in terms of treatment outcomes with better compliance and lower toxicity.

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Published

2020-02-26

How to Cite

Raj, N. D., Yumkhaibam, S. D., Mohanty, S., Chongthu, J. L., & Laishram, J. S. (2020). A comparative study on concurrent chemoradiation using cisplatin versus carboplatin in the management of locoregionally advanced non-small cell lung cancer. International Journal of Research in Medical Sciences, 8(3), 1017–1025. https://doi.org/10.18203/2320-6012.ijrms20200773

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