DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20201307

Histopathological classification of ovarian neoplasm: a retrospective study of 612 cases from a regional cancer centre, Odisha, India

Bagmi Mishra, Madhusmita Rout, Ritu Pradhan, Subhalakhmi Mohapatra, Sashibhusan Dash

Abstract


Background: Ovarian cancer is the leading cause of cancer related death amongst women in India. Identification of histological types helps to predict tumor behaviour and further appropriate management. Aims and objectives is to study the histopathological parameters of ovarian tumor.

Methods: This retrospective study was done on patients who presented ovarian mass and subsequently underwent surgery in a Regional Cancer Centre, Odisha, over a period of three years from January 2016 to December 2018.  All datas such as age, site, gross findings and histological tumor types were retrieved from pathology and analyzed using MS Excel worksheet.

Results: A total 612 cases of ovarian tumor were included for study. Non-neoplastic to neoplastic tumor ratio was 1:7.74. Surface epithelial tumors comprised the majority of tumors, accounting for 452 cases (83.39%). Malignant lesions were predominant in this series 416 cases (76%). Majority of borderline tumors were of mucinous subtype 20 (76.92%). The Mean±SD ages of all benign comprising, borderline and malignant tumors were 47.4±11.9, 44.9±14.3 and 46.9±13, respectively. On the basis of two tired grading system, high grade malignant serous tumors were maximum, 226 (74.34%). Ovarian surface involvement, omental invasion, uterine invasion, LVSI, capsular invasion and pelvic lymph node involvement was observed in 146 (35.26%), 106 (25.6%), 12 (2.89%), 70 (16.9%), 6 (1.44%) and 12 (2.89%) respectively. According to the FIGO staging system, among primary malignant tumor, 58% patients were presented in late stage (III and IV).

Conclusions: The high incidence of malignant ovarian tumor with late presentation was observed in our study. So, further study is warranted to elucidate the major factors in our population.


Keywords


Histopathology, Ovarian neoplasm, Surface epithelial tumor

Full Text:

PDF

References


Ellenson LH, Pirog EC. Ovaries. In: Robbins and Cotran. Pathologic Basis of Disease. South Asia Edition. New Delhi: Reed Elsevier India; 2014:1022.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clinicia. 2018 Nov;68(6):394-424.

Ferlay JS, Soerjomataram I, Ervik M, Dikshit S, Eser C, Mathers M, et al. V1. 0, cancer incidence and mortality worldwide: IARC CancerBase No. 11. 2013. Lyon, France: Int Agency Res Cancer. 2012.

Sharadha SO, Sridevi TA, Renukadevi TK, Gowri R, Binayak D, Indra V. Ovarian masses: Changing clinico histopathological trends. J Obstet Gynecol India. 2015 Feb 1;65(1):34-8.

Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN, et al. Pathology and classification of ovarian tumors. Cancer: Interdisciplinary Int J Am Cancer Soc2003 May 15;97(S10):2631-42.

Mondal SK, Banyopadhyay R, Nag DR, Roychowdhury S, Mondal PK, Sinha SK. Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India. J Cancer Res Therap. 2011 Oct 1;7(4):433.

Martínez-Onsurbe P, Villaespesa AR, Anquela JM, Ruiz PL. Aspiration cytology of 147 adnexal cysts with histologic correlation. Acta Cytologica. 2001;45(6):941-7.

Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective and prospective study of ovarian tumours and tumour-like lesions. Ind J Patho Microbiol. 2007 Jul;50(3):525-7.

Mankar DV, Jain GK. Histopathological profile of ovarian tumours: A twelve year institutional experience. Muller J Med Sci Res. 2015;6(2):107-1.

Lancaster EJ, Muthuphei MN. Ovarian tumours in Africans: a study of 512 cases. Central Afr J Medi. 1995 Aug;41(8):245-8.

Gupta N, Yadav M, Gupta V, Chaudhary D, Patne SC. Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh. J Lab Phys. 2019 Jan;11(1):75.

Kar T, Kar A, Mohapatra PC. Intra-operative cytology of ovarian tumors. J Obstet Gynecol India. 2005;55(4):345-9.

Rai R, Bhutia PC, Tshomo U. Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in Bhutan. South Asian J Cancer. 2019 Jul;8(3):168.

Swamy GG, Satyanarayana N. Clinicopathological analysis of ovarian tumours-A study on five years samples. Nepal Med Coll J. 2010 Dec;12(4):221-3.

Yasmin S, Yasmin A, Asif M. Clinicohistological pattern of ovarian tumours in Peshawar region. J Ayub Med Coll Abbottabad. 2008 Dec 1;20(4):11-3.

Song T, Lee YY, Choi CH, Kim TJ, Lee JW, Bae DS, et al. Histologic distribution of borderline ovarian tumors worldwide: a systematic review. J Gynecol Oncol. 2013 Jan 1;24(1):44-51.

Priya C, Kumar S, Kumar L. Borderline ovarian tumours: An update. Indian J Med Paediatr Oncol. 2008 Apr 1;29(2):19.

Prat J. New insights into ovarian cancer pathology. Ann Oncol. 2012 Sep 1;23(suppl_10):x111-7.

Clement P, Young R. Ovarian Surface Epithelial-Stromal Tumors. In: Mills S, Carter D, Greenson J, Reuter V, Stoler M, eds. Sternberg’s diagnostic surgical pathology. 5th ed. LWW: Philadelphia; 2009:2280.

Gockley A, Melamed A, Bregar AJ, Clemmer JT, Birrer M, Schorge JO, et al. Outcomes of women with high-grade and low-grade advanced-stage serous epithelial ovarian cancer. Obstetr Gynecol. 2017 Mar;129(3):439.

Matz M, Coleman MP, Sant M, Chirlaque MD, Visser O, Gore M, et al. The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2). Gynecol Oncol. 2017 Feb 1;144(2):405-13.

Deodhar KK, Suryawanshi P, Shah M, Rekhi B, Chinoy RF. Immature teratoma of the ovary: a clinicopathological study of 28 cases. Ind Journal Pathol Microbiol. 2011 Oct 1;54(4):730-5.

Zogbi L, Gonçalves CV, Tejada VF, Martins D, Karam F, dos Santos SM, et al. Treatment of bilateral ovarian dysgerminoma with 11-year follow-up: A case report. Ann Medi Surg. 2018 Sep 1;33:50-2.

Young RH. Ovarian sex cord-stromal tumours and their mimics. Pathology. 2018 Jan 1;50(1):5-15.

Jha R, Karki S. Histological pattern of ovarian tumors and their age distribution. Nepal Med Coll J. 2008 Jun 3;10(2):81-5.

Murthy NS, Shalini S, Suman G, Pruthvish S, Mathew A. Changing trends in incidence of ovarian cancer-the Indian scenario. Asian Pac J Cancer Prev. 2009 Jan 1;10(6):1025-30.

Wasim T, Majrroh A, Siddiq S. Comparison of clinical presentation of benign and malignant ovarian tumours. JPMA. J Pak Med Assoc. 2009 Jan 1;59(1):18-20.

Bhattacharyya NK, De A, Bera P, Sristidhar M, Chakraborty S, Bandopadhyay R. Ovarian tumors in pediatric age group-A clinicopathologic study of 10 years’ cases in West Bengal, India. Ind J Med Paediat Oncol: Offi J Indian Society Med Paediat Oncol. 2010 Apr;31(2):54.

Lu KH, Gershenson DM. Update on the management of ovarian germ cell tumors. J Repro Medi. 2005 Jun;50(6):417-25.

Kojimahara T, Nakahara K, Takano T, Yaegashi N, Nishiyama H, Fujimori K, et al. Yolk sac tumor of the ovary: a retrospective multicenter study of 33 Japanese women by Tohoku Gynecologic Cancer Unit (TGCU). Tohoku J Experim Medi. 2013;230(4):211-7.

Tan DS, Kaye S. Ovarian clear cell adenocarcinoma: a continuing enigma. J Clini Pathol. 2007 Apr 1;60(4):355-60.

Dällenbach P, Bonnefoi H, Pelte MF, Vlastos G. Yolk sac tumours of the ovary: an update. Eur J Surgi Oncol (EJSO). 2006 Dec 1;32(10):1063-75.

Babarović E, Franin I, Klarić M, Ferrari AM, Karnjuš-Begonja R, Eminović S, et al. Adult granulosa cell tumors of the ovary: A retrospective study of 36 FIGO stage I cases with emphasis on prognostic pathohistological features. Anal Cell Pathol. 2018;2018.

Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: a study of 282 cases. J Ind Medi Assoc. 2002 Jul;100(7):420-3.

Mangili G, Sigismondi C, Scollo P, Ferrandina G, Candiani M, Angioli R, et al. Management of bilateral malignant ovarian germ cell tumors: a MITO-9 retrospective study. Int J Gynecol Cancer. 2015 Feb 1;25(2):203-7.