DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20200780

Effectiveness of light emitting diode versus conventional phototherapy in neonatal hyperbilirubinemia: a hospital based observational study

Radheshyam Purkait, Manik Mondal

Abstract


Background: The most commonly used light sources in the conventional phototherapy units are compact fluorescent lamp (CFL), halogen spotlights and fiberoptic blankets. Recently light emitting diodes (LED) has emerged as better light source for phototherapy and almost replacing all the available conventional light sources. Comparative studies on the efficacy of LED versus conventional phototherapy are limited from India. That is why; this study was undertaken.

Methods: 48 neonates of ≥35 weeks gestational age with hyperbilirubinemia were participated in this study. Among them, 24 neonates received conventional phototherapy and rest of them received LED phototherapy. The rate of fall of bilirubin levels at 6 hours and at completion along with total duration of phototherapy in both groups was measured. Results analysed by standard statistical methods.

Results: LED phototherapy units showed higher rate of fall in bilirubin at six hrs (LED group: 0.38±0.05 mg/dl/hr versus conventional group: 0.30±0.04 mg/dl/hr, p<0.05) and after completion of therapy (LED group:                      0.32±0.03 mg/dl/hr versus conventional group: 0.26±0.03 mg/dl/hr, p<0.05) compared to conventional group. Significant difference was documented in total duration of phototherapy in LED group (30.8±1.8 hours) when compared to conventional group (34.6±0.7 hours). None of the neonate showed phototherapy failure. Side effects were minimal and comparable in both the groups.

Conclusions: The LED phototherapy units are more efficacious in terms of higher rate of fall of bilirubin levels and lesser duration of phototherapy compared to conventional phototherapy units.


Keywords


Conventional phototherapy, Light emitting diode, Neonatal hyperbilirubinemia, Phototherapy

Full Text:

PDF

References


National Neonatology Forum of India. National Neonatal Perinatal Database Network. Report 2002-2003. New Delhi. 2004.

Ennever JF. Blue light, green light, white light, more light: treatment of neonatal jaundice. Clin Perinatol. 1990;17:467-81.

American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297-316.

McDonagh AF. Phototherapy: from ancient Egypt to the new millennium. J Perinatol. 2001;21(1):7-12.

Vreman HJ, Wong RJ, Stevenson DK, Route RK, Reader SD, Fejer MM, et al. Light-emitting diodes: a novel light source for phototherapy. Pediatr Res. 1998;44(5):804-9.

Martins BM, Carvalho M, Moreira ME, Lopes JM. Efficacy of new microprocessed phototherapy system with five high intensity light emitting diodes (Super LED). J Pediatr. 2007;83(3):253-8.

Maisels MJ, Kring EA, DeRidder J. Randomized controlled trial of light-emitting diode phototherapy. J Perinatol. 2007;27(9):565-7.

Seidman DS, Moise J, Ergaz Z, Laor A, Vreman HJ, Stevenson DK, et al. A prospective randomized controlled study of phototherapy using blue and blue-green light-emitting devices, and conventional halogen-quartz phototherapy. J Perinatol. 2003;23:123-7.

Chang YS, Hwang JH, Kwon HN, Choi CW, Ko SY, Park WS, et al. In vitro and in vivo efficacy of new blue light emitting diode phototherapy compared to conventional halogen quartz phototherapy for neonatal jaundice. J Korean Med Sci. 2005;20:61-4.

Ngerncham S, Jirapaet K, Suvonachai R, Chaweerat R, Wongsiridej P, Kolatat T. Effectiveness of conventional phototherapy versus Super light-emitting diodes phototherapy in neonatal hyperbilirubinemia. J Med Assoc Thai. 2012;95(7):884-9.

Swain N, Nayak MK, Sahoo JP, Panda SK, Rath S. Comparison of effectiveness of light emitting diode (LED) versus compact fluorescent light (CFL) phototherapy in neonatal hyperbilirubinemia. Sch J App Med Sci. 2016;4(8):2830-3.

Reddy TR, Prasad PK, Parakh H, Nagar P. Light-emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a randomised control trial. Int J Pediatr Res. 2014;1(3):67-74.

Gutta S, Shenoy J, Kamath SP, Mithra P, Baliga BS, Sarpangala M, et al. Light emitting diode (LED) phototherapy versus conventional phototherapy in neonatal hyperbilirubinemia: a single blinded randomized control trial from coastal India. Biomed Res Int. 2019;19:62-74.

Takcı S, Yiğit S, Bayram G, Korkmaz A, Yurdakök M. Comparison of intensive light-emitting diode and intensive compact fluorescent phototherapy in non-hemolytic jaundice. Turk J Pediatr. 2013;55(1):29-34.

Mohammadizadeh M, Eliadarani FK, Badiei Z. Is the light-emitting diode a better light source than fluorescent tube for phototherapy of neonatal jaundice in preterm infants? Adv Biomed Res. 2012;1:51.

Kumar P, Kurki S, Malik GK, Chawla D, Deorari AK, Karthi N, et al. Light emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a multi-center randomized controlled trial. Indian Pediatr. 2010;47:131-7.