DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20200803

Pharmacological effects of Sesbania sesban: a systematic review

Michael Nyongesa Walekhwa, Teresa Kerubo Ogeto, Mary Kanyiri Murithi, Zablon Lister Malago

Abstract


The cost, side effects and imitation associated with conventional drugs have driven a substantial number of global citizens to resort to complementary medicine. Although largely informal and unregulated, the practice of herbal medicine is more engrained in low and middle income than in industrialized countries. Sesbania sesban, a plant which grows generously across most parts of the world, has been a major target by most traditional health practitioners. The effects so far reported include antimicrobial, anti-fertility, anti-diabetic, anti-inflammatory among others. No study has reviewed the scholarly works published and jointly reported results. Authros systematically reviewed papers available in different databases to give a hybrid report on the pharmacological effects of Sesbania sesban. A total of three data bases were searched using key terms like: Sesbania sesban, ethno-botany, phytochemical analysis, pharmacological effects etc. A total of 860 papers were initially recovered and further subjected to abstract and title examination which filtered them down to 40 papers. The 40 papers were assessed more against a set of criteria like: in-vivo and in-vitro studies biased to pharmacological effects of the plant, studies that were less than 15 years old and studies that used experimental design. This further scrutiny reduced the number of papers to 25. Most studies reported Sesbania sesban as having great anti-microbial, anti-fungal, anti-inflammatory and anti-diabetic qualities. No study reported any adverse effect of the plant. Authors recommend a dose-effect assessment and mechanism of action of the plant extracts especially with regard to the antimicrobial, anti-inflammatory and anti-fertility qualities.


Keywords


Anti-fertility and Pharmacological effects, Anti-inflammatory, Antimicrobial, Sesbania sesban, Systematic review

Full Text:

PDF

References


Organisation mondiale de la santé. WHO traditional medicine strategy 2002-2005. World Health Organization; 2002.

Nirmal SA, Pal SC, Mandal SC, Mandal SC. Pharmacovigilance of herbal medicines. Pharma Times. 2014:19.

Nweneka CV, Tapha-Sosseh N, Sosa A. Curbing the menace of antimicrobial resistance in developing countries. Harm redu J. 2009 Dec 1;6(1):31.

Barnes J, Anderson LA. Herbal medicines. 3rd ed. London: Pharm Press; 2007:1-28.

Mills E, Dugoua JJ, Perri D, Koren G. Herbal medicines in pregnancy and lactation: an evidence-based approach. CRC press; 2006 Jan 17.

Chanda SC, ud Doula AA, Sarwa AG. Screening of Sesbania accessions based on early biomass yield. J Bang Agricul Univ. 2017 Dec 29;15(2):188-92.

Desaeger J, Rao MR. The potential of mixed covers of Sesbania, Tephrosia and Crotalaria to minimise nematode problems on subsequent crops. Field Crops Res. 2001 Apr 20;70(2):111-25.

Nigussie Z, Alemayehu G. Sesbania sesban (L.) Merrill: Potential uses of an underutilized multipurpose tree in Ethiopia. Afr J Plant Sci. 2013 Oct;7(10):468-75.

Usman MR, Patil SB, Patil SS, Patil RS. Sesbania sesban Linn.: An overview. Int J of Pharm Life Sci.(IJPLS). 2013 May;4(5):2644-8.

Kathiresh M, Suganya Devi MS. Bioactive compounds in Sesbania sesban flower and its Antioxidant and Antimicrobial activity Bioactive compounds in Sesbania sesban flower and its Antioxidant and Antimicrobial activity. J Pharm Res. 2012;(5):390-293.

Vitti DM, Abdalla AL, Bueno IC, Silva Filho JC, Costa C, Bueno MS, et al. Do all tannins have similar nutritional effects? A comparison of three Brazilian fodder legumes. Animal Feed Sci Technol. 2005 Apr 4;119(3-4):345-61.

Oosting SJ, Mekoya A, Fernandez-Rivera S, Van der Zijpp AJ. Sesbania sesban as a fodder tree in Ethiopian livestock farming systems: Feeding practices and farmers' perception of feeding effects on sheep performance. Livestock Sci. 2011 Jul 1;139(1-2):135-41.

Goel G, Makkar HP, Becker K. Effects of Sesbania sesban and Carduus pycnocephalus leaves and Fenugreek (Trigonella foenum-graecum L.) seeds and their extracts on partitioning of nutrients from roughage-and concentrate-based feeds to methane. Animal Feed Sci Technol. 2008 Nov 14;147(1-3):72-89.

Mythili T, Ravindhran R. Phytochemical screening and antimicrobial activity of Sesbaniasesban (L.) Merr. Asian J Pharma Clin Res. 2012;5(4):18-23.

Hossain MA, Rahman MS, Chowdhury AS, Rashid MA. Bioactivities of Sesbania sesban Extractives. Dhaka Univ J Pharma Sci. 2007;6(1):61-3.

Nirosha M, Kankanala Pavani AKP, Urimilla Haseena SJ. Antimicrobial activity of organic leaf extract of Sesbania sesban against gram negative pathogenic bacteria. Int J Life Sci Pharma Res. 2019;(9):31-8.

Sajid S, Vijay P, Usman R. Anti-inflammatory activity of Sesbania sesban (L) Merr. Int Res J Pharm. 2012;(3):176-80.

Tatiya AU, Dande PR, Mutha RE, Surana SJ. Effect Of Saponins From Of SesbaniasesbanL.(Merr) On Acute And Chronic Inflammation in Experimental Induced Animals. J Biol Sci. 2013 Apr 1;13(3):123-30.

Hasheesh WS, Mohamed RT, El-Monem SA. Biological and physiological parameters of Bulinus truncatus snails exposed to methanol extract of the plant Sesbania sesban plant. Advan Biol Chem. 2011 Nov 7;1(03):65.

Mahmoud MB, Ibrahim WL, Abou-El-Nour BM, El-Emam MA, Youssef AA. Biological and biochemical parameters of Biomphalaria alexandrina snails exposed to the plants Datura stramonium and Sesbania sesban as water suspensions of their dry powder. Pesticide Biochem Physiol. 2011 Jan 1;99(1):96-104.

Kutchan TM. Ecological arsenal and developmental dispatcher. The paradigm of secondary metabolism. Plant Physiol. 2001 Jan 1;125(1):58-60.

Pandhare RB, Sangameswaran B, Mohite PB, Khanage SG. Antidiabetic activity of aqueous leaves extract of Sesbania sesban (L) Merr. in streptozotocin induced diabetic rats. Avicenna J Med Biotechnol. 2011 Jan;3(1):37.

Aggarwal N, Gupta P. Effect of petroleum ether extract of Sesbania sesban (Merr.) roots in streptozotocin (STZ) induced diabetes in mice. Asian Pacific J Trop Biomed. 2012 Jan 1;2(3):S1254-60.

Pandhare RB, Sangameswaran B, Mohite PB, Khanage SG. Aqueous extracts of the leaves of Sesbania sesban reduces development of diabetic nephropathy in streptozotocin-induced diabetic rat. Bangladesh J Pharmacol. 2010;5(2):103-6.

NN N, Tare HL, Sherikar AK, Deore SR. and Dama GY; Central nervous system stimulant effect of extracts obtained from the barks of Sesbania Sesban. Intern J Institu Pharmacy Life Sci. 2011;1(1):77-92.

Padumanonda T, Johns J, Sangkasat A, Tiyaworanant S. Determination of melatonin content in traditional Thai herbal remedies used as sleeping aids. DARU J Pharma Sci. 2014 Dec 1;22(1):6.

Dande PR, Talekar VS, Chakraborthy GS. Evaluation of crude saponins extract from leaves of Sesbania sesban (L.) Merr. for topical anti-inflammatory activity. International J Res Pharma Sci. 2010 Jul 25;1(3):296-9.

Das N, Chandran P, Chakraborty S. Potent spermicidal effect of oleanolic acid 3-beta-D-glucuronide, an active principle isolated from the plant Sesbania sesban Merrill. Contraception. 2011 Feb 1;83(2):167-75.

Nirmal SA, Bairagi JH, Patil AN, Pal SC, Upasani CD, Mandal SC. Antinociceptive activity of Sesbania sesban (Linn) wood extracts, a preliminary study. Ind J Exp Biol. 2012;(50):61-4.