DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20201321

A study of dyslipidemias in newly diagnosed hypertensive patients

Pallavi Arangi, Rajya Lakshmi Medabalimi, Anand Acharya

Abstract


Background: Dyslipidemia and hypertension are a major, common and modifiable risk factor for diseases like a stroke; coronary artery disease etc. which are common causes for mortality in India. Dyslipidemia and hypertension are usually found co-exist, which accelerates the process of atherosclerosis.

Methods: It is a cross-sectional study conducted on the patients who are newly diagnosed hypertensive visited Medical OPD in Konaseema institute of medical sciences between January 2018 to June 2019. All were investigated for various clinical parameters on lipid profile abnormalities. Results were compared among cases and controls.

Results: A total number of patients included in the study were 167,107 are cases and 60 controls. Significant higher levels of total cholesterol, triglycerides, LDL-c and lower levels of HDL-c were observed in hypertensive patients with p-value significant <0.0001.

Conclusions: Hypertensive patients have significantly elevated levels of all forms of cholesterol and a higher percentage of individuals in the dyslipidemic state when compared with normotensive patients. Pre-diabetic state significantly increases the total cholesterol in hypertensive patients.


Keywords


Dyslipidemia, Hypertension, Metabolic syndrome

Full Text:

PDF

References


Web site, Hypertension fact sheet. World Health Organisation Regional Office of South East Asia 2011. Available at: https://www.who.int/news-room/fact-sheets/detail/hypertension. Accessed on 10 December 2019.

Web site, WHO. A global brief on hypertension: silent killer, global public health crisis. World Health Organization 2013. WHO/DCO/WHD/2013.2 Available at: https://www.who.int/publications-detail/a-global-brief-on-hypertension-silent-killer-global-public-health-crisis-world-health-day-2013. Accessed on 10 December 2019.

Theodore AK. Hypertensive Vascular Diseases. Jameson, Fauci, Kasper, Hauser, Longo, Loscalzo edi. In: Harrison’s Principles of Internal Medicine. 20th ed. McGraw Hill; 2018:1890.

Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):1269-324.

Guptha S. Lipids and Lipoprotein Metabolism. In: API Textbook of Medicine.10th ed. Jaypee; 2015:1690.

Semenkovich CF, Goldberg AC, Goldberg IJ. Disorders of Lipid Metabolism. Schlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, Henry M. Kronenberg eds. In: Williams Textbook of Endocrinology. 13th ed. Elsevier; 2016:1682.

Dalal JJ, Padmanabhan T, Jain P, Patil S, Vasnawala H, Gulati A. Lipitension: Interplay between dyslipidemia and hypertension. Indian J Endocr Metab. 2012;16(2):240-5

Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5-6):231-7.

Mather A, Burnett L, Sullivan DR, Stewart P. Clinical Biochemistry and metabolic medicine. Stuart H. Ralston, Ian D. Penman, Mark W.J. Strachan, Richard P. Hobson editors. In: Davidson’s Principles and Practice of Medicine. 23rd ed. Elsevier; 2018:373.

Idemudia J, Ugwuja E. Plasma lipid profile in hypertensive Nigerians. Int J Cardiov Res. 2009;6(22):1-6.

Saha MS, Sana NK, Shaha RK. Serum Lipid Profile of Hypertensive Patients in the Northern Region of Bangladesh. J Bio Sci. 2006;14:93-98.

Abdullae A, Kerke NN, Obineche R. Biochemical markers and lipid profiles in multicentric population in UAE, JNRI. 2008;1(1);23-31

Rueda D, Maldonado A, Alonso A, Soto JA, Soriano L, Munoz F. Hypertension. Austrel Med J. 2017 Apr;24(2):104-110.

Hilal Y, Acar TN, Koksal E, Gezmen KM, Akbulut G, Bilici S, et al. The association of anthropometric measurements and lipid profiles in Turkish hypertensive adults. Afr Health Sci. 2011;11(3):407-13.

Grundy SM. Pre-diabetes, metabolic syndrome, and cardiovascular risk. J Am Coll Cardiol. 2012;59:635-43.