Published: 2020-10-28

A rare case of deep vein thrombosis in upper extremity: a case report

Mohammed Adnan Sheerazi, Furqan Mohd. Akram Khan


The incidence of deep vein thrombosis (DVT) in upper limb is less common as compared to lower extremities. There were no institutional screening protocols for patients at risk of DVT in upper limb. Hence this case report was presented to describe the features of upper limb DVT.


Upper limb deep vein thrombosis, Activated factor VIII, Protein C, Vitamin K

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Schwarz HP, Fischer M, Hopmeier P, Batard MA, Griffin JH. Plasma protein S deficiency in familial thrombotic disease. Blood. 1984;64:1297-300.

Comp PC, Nixon RR, Cooper MR, Esmon CT. Familial protein S deficiency is associated with recurrent thrombosis. J Clinical Invest. 1984;74:2082-8.

Broekmans AW, Bertina RM, Reinalda-Poot J, Engesser L, Muller HP, Leeuw JA. Hereditary protein S deficiency and venous thromboembolism. A study in three dutch families. Thromb Haemostas. 1985;53:273–7.

Coller BS, Owen J, Jesty J, Horowitz D, Reitman MJ, Spear J. Deficiency of plasma protein S, protein C or antithrombin III and arterial thrombosis. Arteriosclerosis. 1987;7(5):456-62.

Manucci PM, Tripodi A, Bertina RM. Protein S deficiency associated with “juvenile” arterial and venous thrombosis. Thromb Haemostas. 1986;55:440.

Howard DP, Banerjee A, Fairhead JF, Hands L, Silver LE, Rothwell PM. Population-based study of incidence, risk factors, outcome, and prognosis of ischemic peripheral arterial events: implications for prevention. Circulation. 2015;132:1805-15.

Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2095-128.

Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FGR. Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg. 2007;45:67.

Smith D, Bhimji S. Acute Arterial occlusion. StatPearls. Treasure Island (FL): StatPearls Publishing. 2017.

Marlar RA, Gausman JN. Protein S abnormalities: a diagnostic nightmare. Am J Hematol. 2011;86(5):418-21.

Hackeng TM, Rosing J. Protein S as cofactor for TFPI. Arterioscler Thromb Vasc Biol. 2009;29(12):2015-20.

Heeb MJ, Rosing J, Bakker HM, Fernandez JA, Tans G, Griffin JH. Protein S binds to and inhibits factor Xa. Proc Natl Acad Sci. 1994;91(7):2728-32.

Lieu PK, Lee SH, Tan CB, Tan ES. Recurrent cerebral thrombosis associated with Protein S deficiency in a Chinese female. Singapore Med J. 1992;33:418-9.