Evaluation of cognitive functions in diabetic patients

Authors

  • Emre Cakir Department of Medical Oncology, Sakarya University Medicine Faculty, Sakarya, Turkey
  • Nazmiye Ozlem Harmankaya Department of Nephrology, Biruni University Medicine Faculty, Istanbul, Turkey
  • Hasret Cengiz Department of Endocrinology, Sakarya University Medicine Faculty, Sakarya, Turkey
  • Ceyhun Varim Department of Internal Medicine, Sakarya University Medicine Faculty, Sakarya, Turkey

DOI:

https://doi.org/10.18203/2320-6012.ijrms20202240

Keywords:

Diabetes Mellitus, Cognitive functions, Hemoglobin A1c

Abstract

Background: Diabetes Mellitus is an independent risk factor for cognitive impairment and dementia. In this study, authors investigated cognitive functions in the diabetes and control group with Mini Mental State Examination (MMSE). Authors analyzed the association of cognitive status with age, sex, duration of diabetes, insulin use and HbA1c in diabetic patients.

Methods: Fifty patients with diabetes diagnosed between the ages of 50 and 70 who applied to this Diabetes and General Internal Medicine Clinics between January 2017 and September 2017 were included. Fifty patients with nondiabetes diagnosed with similar age and demographic characteristics were included in the control group. MMSE was applied to both groups. In the diabetic group, cognitive functions were investigated in relation with age, gender, duration of diabetes, insulin usage and HbA1c.

Results: The MMSE score in diabetic patients was lower than the control group (p<0.05). In addition, cognitive impairment in diabetic patients was associated with duration of diabetes and HbA1c level. There wasn't significant difference was found between cognitive impairment and age, sex, insulin use.

Conclusions: Diabetes Mellitus is a risk factor for cognitive impairment and dementia with many possible mechanisms. In the routine, there is no screening for cognitive impairment and dementia in diabetic patients; but if authors detect early cognitive impairment, authors can prevent cognitive impairment progression to dementia with medical treatment and cognitive exercises.

References

Saygili F, Satman I, TEMD (Turkey Association of Endocrine and Metabolism) Diabetes Mellitus and its Complications of Diagnosis, Treatment and Monitoring Guide. 6th ed. Byte Scientific Research, Ankara. 2013: 22-24.

Arvanitakis Z, Wilson RS, Li Y, Aggarwal NT, Bennett DA. Diabetes and its function in different cognitive systems in older indiv-iduals without dementia. Diab Care. 2006;29(3):560-65.

Velayudhan L, Poppe M, Archer N, Proitsi P, Brown RG, Lovestone S. Risk of developing dementia in people with diabetes and mild cognitive impairment. Br J Psych. 2010 Jan;196(1):36-40.

Whitmer RA. Type 2 diabetes and the risk of cognitive impairment and dementia. Curr Neurol Neurosci Rep. 2007;7(5):373-80.

Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006;5:64-74.

Mogi M, Horiuchi M. Neurovascular coupling in cognitive impairment associated with diabetes mellitus. Circulat J. 2011;75(5):1042-8.

Gregg EW, Yaffe K, Cauley JA, Rolka DB, Blackwell TL, Narayan KM, et al, Is diabetes associated with cognitive impairment and cognitive decline among older women? Study of Osteoporotic Fractures Research Group. Arch Intern Med. 2000;160:174-80.

Gao Y, Xiao Y, Miao R, Zhao J, Cui M, Huang G, et al. The prevalence of mild cognitive impairment with type 2 diabetes mellitus among elderly people in China: A cross-sectional study. Arch Gerontol Geriatr. 2016 Jan-Feb;62:138-42.

Crum RM, Anthony JC, Bassett SS, Folstein MF. Population-based norms for the Mini-Mental State Examination on the basis of the age and the educational level. JAMA. 1993;269(18):2386-91.

Alencar RC, Cobas RA, Gomes MB. Assessment of the cognitive status in patients with type 2 diabetes through the Mini Mental Status Examination: a cross sectional study. Diabetol Metab Syndr. 2010;2:10.

Maggi S, Limongi F, Noale M, Romanato G, Tonin P, Rozzini R, et al. Diabetes as a risk factor for cognitive decline in older patients. Dement Geriatr Cognit Disord. 2009;27(1):24-33.

Okereke OI, Kang JH, Cook NR, Gaziano JM, Manson JE, Buring JE, et al. Type 2 diabetes mellitus and cognitive decline in two large cohorts of community‐dwelling older adults. J Am Geriatr Soc. 2008 Jun;56(6):1028-36.

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Published

2020-05-26

How to Cite

Cakir, E., Harmankaya, N. O., Cengiz, H., & Varim, C. (2020). Evaluation of cognitive functions in diabetic patients. International Journal of Research in Medical Sciences, 8(6), 2039–2043. https://doi.org/10.18203/2320-6012.ijrms20202240

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Original Research Articles