Use of stem cells in tissue engineering and reconstruction of the maxillofacial region

Pankaj Kukreja, Modi Fahd Al Qahtani, Majedah Fahd Al Qahtani, Ahad Fahd Al Qahtani, Bhavna Jha Kukreja


The oral and craniofacial defect reconstruction has been a daunting task for several decades. Many clinicians have attempted to switch surgical techniques in flap transfer to enhance the purposeful outcomes. In many cases, however, near total restoration of the native anatomy is not achievable. Also, the normal functional performance is not attainable, regardless of the surgical technique used. This problem is more evident within the oral and craniofacial region considering the importance of functions, such as speech, chewing, and appearance. Stem cells have attracted a growing interest within the scientific community chiefly for their ability to regenerate broken tissues and conjointly for their known potential in modulating inflammatory and immune responses. These skills have caused stem cells to be thought about as a promising strategic tool for a range of clinical maxillofacial applications. In this review, authors briefly summarize the applications of stem cells in maxillofacial surgery. 


Maxillofacial, Reconstruction, Stem cells, Tissue engineering

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