Bone marrow involvement as a rare manifestation of relapsed choroidal melanoma

Authors

  • Nusrat Bashir Department of Pathology, GMC, Srinagar, Jammu and Kashmir, India
  • Farzana Manzoor Department of Pathology, GMC, Srinagar, Jammu and Kashmir, India
  • Bilal Musharaf Department of Pathology, GMC, Srinagar, Jammu and Kashmir, India
  • Ruby Reshi Department of Pathology, GMC, Srinagar, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20203475

Keywords:

Bone marrow, Choroidal, Melanoma, Metastasis

Abstract

Choroidal Melanoma is the most common primary intra-ocular malignancy. Incidence of primary choroidal melanoma is about 6 cases per 1 million population. It disseminates hematogenously. The most common site of metastasis is liver. Metastatic melanoma involving the bone marrow is rare, occurring in 5% of patients with disseminated disease. However, Choroid melanoma with bone marrow involvement is very rare. Only a few case reports are published in literature.  Authors present a case of bone marrow metastasis from choroid melanoma in 55 years old female who has been treated for primary choroidal melanoma by enucleation of left eye three years back. In the evaluation of symptomatic anemia, features suggestive of bone marrow infiltration by choroidal melanoma were observed on bone marrow aspiration and biopsy. The diagnosis was confirmed by positivity of immune-histochemistry markers HMB-45 and Melana.

References

Damato B, Eleuteri A, Taktak AF, Coupland SE. Estimating prognosis for survival after treatment of choroidal melanoma. Prog Retin Eye Res 2011;30:285-95.

Collaborative Ocular Melanoma Study Group. Assessment of metastatic disease status at death in 435 patients with large choroidal melanoma in the Collaborative Ocular Melanoma Study (COMS): COMS report 15. Arch Ophthalmol 2001;119:670-6.

Serrier C, Lesesve JT. Metastatic malignant melanoma in bone marrow: Am Soc Hematol, Blood. 2013;121:721.

Hsiao SY, Chen TY. Uveal Melanoma wuth diffuse bone marrow involvement: Am Soc Hematol Blood. 2014;124:1996.

Shiozaw Y, Ebew MR, Berry JE, Taichman RS. Bone Marrow as amatastatic niche for disseminated tumor cells from solid tumors. Bonekey Reports. 2015;689.

Tas F. Metastatic behavior in melanoma: timing, pattern, survival, and influencing factors. J Oncol. 2012 Oct;2012.

Singh G, Krause JR, Breitfeld V. Bone marrow examination for metastatic tumor. Cancer. 1977;40:2317-21.

Bearden JD, Ratkin GA, Coltman CA. Comparison of the diagnostic value of bone marrow biopsy and bone marrow aspiration in neoplastic disease. J Clin Pathol. 1974;27:735-40.

Yaziji H, Gown AM. Immunohistochemical markers of melanocytic tumors. Int J Surg Pathol. 2003;11(1):11-5.

Bacchi CE, Bonetti F, Pea M, Martignoni G, Gown AM. HMB-45: A review. Appl Immunohistochem 1996;4:73-85.

Downloads

Published

2020-07-24

How to Cite

Bashir, N., Manzoor, F., Musharaf, B., & Reshi, R. (2020). Bone marrow involvement as a rare manifestation of relapsed choroidal melanoma. International Journal of Research in Medical Sciences, 8(8), 3110–3112. https://doi.org/10.18203/2320-6012.ijrms20203475

Issue

Section

Case Reports