Hepatitis B virus and hepatitis C virus co-infection among outdoor patients and indoor patients of tertiary care institute, Bathinda, Punjab, India

Authors

  • Lovepreet Singh Department of Microbiology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India
  • Swati Mittal Department of Microbiology, Adesh Medical College and Hospital, Shahbad (M), Kurukshetra, Haryana, India
  • Amandeep Kaur Department of Microbiology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India
  • Surinder Singh Department of Microbiology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India
  • Ravi K. Tiwary Department of Neurosurgery, Adesh Medical College and Hospital, Shahbad (M), Kurukshetra, Haryana, India
  • Harjinder Singh Department of Microbiology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20203672

Keywords:

Anti-hepatitis C virus antibodies, Hepatitis B surface antigen, Hepatitis virus infection, Hepacard, Tri-dot

Abstract

Background: Hepatitis virus infections have many serious consequences like chronic hepatitis, fulminant hepatitis, liver cirrhosis, hepatocellular carcinoma and liver cancer. Serological test is thus necessary to identify hepatitis virus in the body. An observational study was conducted with an objective to detect hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) antibodies by rapid card tests and to find the prevalence of co-infection with hepatitis B and hepatitis C viruses from January 2019 to June 2019.

Methods: Blood samples were received from patients irrespective of age and sex, constituted the material for the present study. All samples were tested on hepacard and tri-dot card for the detection of hepatitis B virus and hepatitis C virus and results were interpreted as per Clinical Laboratory Standards Institute guidelines.

Results: Out of 3488 samples, 254 samples were positive for hepatitis virus infection. Out of these 254 samples positive for hepatitis viruses, 22 (0.6%) patients were positive for hepatitis B virus and 232 (6.6%) patients were positive for hepatitis C virus. Only 2 (0.7%) of these patients showed co-infection with both viruses.

Conclusions: Male patients showed more positivity of hepatitis virus as compared to females. Patients were more from outpatient department (OPD) as compared to inpatient department (IPD). Hepatitis virus infection was found to be highest in the age group 21-40 and lowest in the age group above 80 years. Both the co-infected patients were males and from IPD.

 

Author Biography

Lovepreet Singh, Department of Microbiology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India

Department of microbiology, Senior tutor

References

Sastry AS, Sandhya BK. Essentials of medical microbiology. 1st edn. Jaypee Brothers Medical Publishers (P) Ltd. Ansari Road, Daryaganj, New Delhi; 2016:527-38.

Baveja CP. Textbook of microbiology. 5th edn. Arya Publications, Industrial Area, Trilokpur Road, Kala Amb, Sirmour (HP); 2017:497-504.

Ho E, Hees SV, Goethals S, Smits E, Huizing M, Francque S, et al. Biobanking for viral hepatitis research. Front Med. 2019;6:183.

Cakir OO, Toker A, Ataseven H, Demir A, Polat H. The importance of liver-fatty acid binding protein in diagnosis of liver damage in patients with acute hepatitis. J Clin Diag Res. 2017;11(4):17-21.

Bernal W, Wendon J. Acute liver failure. New Engl J Med. 2013;69:25-34.

Khashab M, Tector AJ, Kwo PY. Epidemiology of acute liver failure. Curr Gastroenterol Rep. 2007;9(1):66-73.

Liang TJ. Hepatitis B: the virus and disease. Hepatol. 2009;49(5):13-21.

Caccamo G, Saffioti F, Raimondo G. Hepatitis B virus and hepatitis C virus dual infection. World J Gastroenterol. 2014;20(40):14559-67.

Ananthanarayan R, Panikar JCK. Textbook of Microbiology. 10th edn. Orient Longman Private Ltd. Anna Salai, Chennai; 2017;58:544-53.

Manns MP, Buti M, Gane E, Pawlotsky JM, Razavi H, Terrault N, et al. Hepatitis C virus infection. Nature Rev Dis Prim. 2017;3:17006.

Bastos JCS, Padilla MA, Caserta LC, Miotto N, Vigani AG, Arns CW. Hepatitis C virus: promising discoveries and new treatments. World J Gastroenterol. 2016;22(28):6393-401.

Li HC, Lo SY. Hepatitis C virus: virology, diagnosis and treatment. World J Hepatol. 2015;7(10):1377-89.

Munir S, Saleem S, Idrees M, Tariq A, Butt S, Rauff B, et al. Hepatitis C treatment: current and future perspectives. Virol J. 2010;7:296.

Merz A, Long G, Hiet MS, Brugger B, Chlanda P, Andre P, et al. Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem. 2011;286(4):3018-32.

Malhotra R, Soin D, Grover P, Galhotra S, Khutan H, Kaur N. Hepatitis B virus and hepatitis C virus co-infection in hemodialysis patients: a retrospective study from a tertiary care hospital of North India. J Nat Sci Biol Med. 2016;7(1):72-4.

Desikan P, Khan Z. Prevalence of hepatitis B and hepatitis C virus co-infection in India: a systematic review and meta-analysis. Ind J Med Microbiol. 2017;35(3):332-9.

Papadopoulos N, Papavdi M, Pavlidou N, Konstantinou D, Kranidioti H, Kontos G, Koskinas J, et al. Hepatitis B and C coinfection in a real-life setting: viral interactions and treatment issues. Ann Gastroenterol. 2018;31(3):365-70.

Konstantinou D, Deutsch M. The spectrum of HBV/HCV coinfection: epidemiology, clinical characteristics, viralinteractions and management. Ann Gastroenterol. 2015;28(2):221-8.

Liu Z, Hou J. Hepatitis B Virus (HBV) and hepatitis C virus (HCV) dual infection. Int J Med Sc. 2006;3(2):57-62.

Brass V, Moradpour D. New insights into hepatitis B and C virus co-infection. J hepatol. 2009;51(3):423-5.

Gaeta GB, Stornaiuolo G, Precone DF, Stroffolini T, Colucci G, Rizetto M, et al. Epidemiological and clinical burden of chronic hepatitis B virus/hepatitis C virus infection. A multicenter Italian study. J Hepatol. 2003 39(6):1036-41.

Hassuna NA, Mohamed ZM, Abo-Eluoon SM, Abdel-Hamid M, et al. Prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) infections and their co-infection among blood donors in Minia Governorate, Egypt. Br J Med Med Res. 2015;5(8):987-93.

Baseke J, Musenero M, Mayanja-Kizza H, et al. Prevalence of hepatitis B and C and relationship to liver damage in HIV infected patients attending Joint Clinical Research Centre Clinic (JCRC), Kampala, Uganda. Afr Health Sci. 2015;15(2):322-7.

Lin PY, Chen SC, Lo TC, Kuo HW. Dual infection with hepatitis B virus and hepatitis c virus correlated with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2020;128(1):38-42.

Junejo SA, Khan NA, Lodhi AA. Prevalence of hepatitis B and C infection in patients admitted at tertiary eye care centre: a hospital-based study. Pak J Med Sci. 2009;25(4):597-600.

Agarwal L, Singh AK, Agarwal A, Singh RP. Incidental detection of hepatitis B and C viruses and their coinfection in a hospital-based general population in tertiary care hospital of Uttar Pradesh. J Family Med Prim Care. 2018;7(1):157-61.

Omote V, Kashibu E, Ojumah I, Adda D, Etaghene J, Ukwamedua J. Serological screening of hepatitis B virus and hepatitis C virus among patients attending a tertiary hospital in Jalingo, Taraba state, Nigeria. Saudi J Health Sci. 2018;7(3):167-71.

Khan J, Shafiq M, Mushtaq S, Ayaz S, Ullah R, AbdEI-Salam NM, et al. Seropositivity and coinfection of hepatitis B and C among patients seeking hospital care in Islamabad, Pakistan. BioMed Res Int. 2014;516859:4.

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Published

2020-08-26

How to Cite

Singh, L., Mittal, S., Kaur, A., Singh, S., Tiwary, R. K., & Singh, H. (2020). Hepatitis B virus and hepatitis C virus co-infection among outdoor patients and indoor patients of tertiary care institute, Bathinda, Punjab, India. International Journal of Research in Medical Sciences, 8(9), 3252–3255. https://doi.org/10.18203/2320-6012.ijrms20203672

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Original Research Articles