Oral versus intravenous maternal hydration in isolated third trimester oligohydramnios

Humaira Zafar, Mubashra Naz, Umber Fatima, Uzma Shahzad, Anees Fatima, Attiya Yasmeen


Background: To study the effect of oral and intravenous maternal hydration in patients with isolated oligohydramnios in terms of mean change in amniotic fluid.

Methods: A total number of 38 patients included in the study which fulfill the selection criteria.  Patients were randomly divided in two groups. Amniotic fluid index (AFI) of all patients was measured before the hydration therapy according to the method of Phelan et al.  In maternal oral hydration (Group A), every patient was instructed to drink two liters of water over two hours daily for 1 week. In intravenous hydration (Group B), every woman infused two liters of 0.9% normal saline in two hour daily for 1 week. After 48 hours and 1 week of oral and intravenous hydration, the AFI was reassessed by the same observer. Patients were monitored closely for sign and symptoms of fluid overload. Data was stratified for mean difference in improvement in amniotic fluid index.

Results: After oral hydration therapy AFI was 5.926±0.4593 after 48 hours and 8.286±0.6000 after 7 days in Group A. In Group B AFI was 5.784±0.4622 after 48 hours and 7.868±0.2810 after 7 days of intravenous hydration. P value after 48 hours is 0.348 and p=0.014 after 7 days means oral hydration therapy significantly increase amniotic fluid index.

Conclusions: Oral maternal hydration significantly increase the amniotic fluid index in patients with isolated oligohydramnios. It is simple, safe and non-invasive method.


Amniotic fluid index, Intravenous hydration, Isolated oligohydramnios, Oral hydration

Full Text:



Patel A, Yadav K, Goswami G. All effects of oral and intravenous therapy on amniotic fluid index, maternal and perinatal outcome in isolated oligohydramnios. Europ J Biomedic Pharmaceutic Scienc. 2016;(3)6:316-21.

Ali H, Ahmed S. The effect of oral versus intravenous fluid therapy on maternal and neonatal outcomes for women with oligohydramnios. 2018;(15)3:228-35.

Bhat S, Kulkarni V. Study of effects of oligohydramnios on maternal and fetal outcome. Int J Medic Develop Count. 2015;4:582-8.

Nada Z. Oral and intravenous maternal hydration in third trimester idiopathic oligohydramnios: effects and duration. J Nurs Heal Scien. 2015;(4)5:22-5.

Zafar AF, Maqsood S, Niaz A, Noor S, Javed N. Comparison of Mean Amniotic Fluid Index in Maternal Oral Hydration Therapy with Routine Hydration in Third Trimester Oligohydramnios. Anna Punja Medic Colle. 2017;11(3):257-60.

Krishnaveni MA study of fetal outcome in oligohydramnios (AFI between0-7). J Eveide Base Med Healthc. 2015;2(12):1801-11.

Asnafi N, Bouzari Z, Mohammadnetadj M. Oligohydramnios and pregnancy outcome: Ten-years review. Int Biolog Biomedic J. 2015;1(1): 23-8.

Gizzo S, Noventa M, Vitagilano. An update on maternal hydration strategies for amniotic fluid improvement in isolated oligohydramnios and normohydramnios: Evidence from a systemic Review of Literature and Mete- Analysis. PLo On. 2015;10(12):e0144334.

Patil N, Abhigna V. A randomized controlled trial to compare the efficacy of three different methods of maternal hydration for oligohydramnios. J Krish Institu Medic Scienc Univer. 2018;7(1).

Momina SB, Akhtar M, Akram M, Yasmeen S. Comparison of the effects of oral and intravenous maternal hydration in the management of third trimester oligohydramnios. Biomedica. 2012;28: 126-9.

Akhtar MD, Kabir N, Shah MS, Islam F, Tasnim. Effects of maternal oral hydration therapy in oligohydramnios. Mymenish Med J. 2012;21:723-8.

Rossi AC, Prefumo F. Perinatal outcome of isolated oligohydramnios at term and post term pregnancy: a systematic review of literature with meta – analysis. Eur J Obstet Gynecol Biol. 2013;169(2):149-54.

Kiran S, Ameen A, Akram A, Jamil M. Comparison of effects of oral maternal hydration and intravenous infusion on Amniotic Fluid index in third trimester isolated oigohydramnios. Professional Med J. 2019; 26(12):2064-9.

Chauhan NS, Namdeo P, Modi JN. Evidence based management of oligohydramnios. J Gynecol. 2018; 3(3)000160.