DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20204235

A study on scrape smear cytology in oral leukoplakia in a tertiary health care centre of southern Assam

Sania S. Ullah, Manoj K. Deka, Nitumani Khakhlari

Abstract


Background: Oral cavity is susceptible to countless changes with advancing, environmental, and lifestyle related habits and factors. Oral mucosal lesions especially related to chewing and smoking of tobacco have led to the increased incidence and prevalence of potentially malignant and malignant disorders worldwide. Oral leukoplakia has been a very frequent finding in patients coming to our department and with an increasing rise of oral squamous cell carcinoma in the region, the study was conducted.

Methods: Patients referred to our section from various department with white oral lesion. Scrapping smears were prepared. Stained with MGG and PAP stain. Study period: January 2019 to May 2020.

Results: Total number of patients with white oral lesion were 83. Out of these 65 were male and 18 were female. Most of the patients had addiction to betel nut and leaf with tobacco and few had history of intake of bidi for several years.

Conclusions: The study reveals that most of the oral leukoplakia cases is attributed to smoking, betel nut and lime intake. Exfoliative cytology of oral mucosa serves to be an easy, convenient and reproducible technique for early diagnosis of premalignant condition. Biopsy can be used as an adjunct in cases showing atypia and mixed type of keratosis.


Keywords


Cytology, Leukoplakia, Oral cavity

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References


Acha A, Ruesga MT, Rodríguez MJ, Martínez de Pancorbo MA, Aguirre JM. Applications of the oral scraped (exfoliative) cytology in oral cancer and precancer. Med Oral Patol Oral Cir Bucal 2005;10:95–102.

Cowpe JG, Longmore RB, Green MW. Quantitative exfoliative cytology of abnormal oral mucosal smears. J R Soc Med 1988;81:509–13.

van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol 2009;45:317–23.

van der Waal I, Schepman KP, van der Meij EH, Smeele LE. Oral leukoplakia: A clinicopathological review. Oral Oncol 1997;33:291–301.

Usta U, Berberoglu U, Helvaci E, Altaner S, Sut N, Ozdemir C. Evaluation of cytological alterations in normal-appearing oral mucosal epithelia of smokers and non-smokers via Agnor counts and nuclear morphometry. Balkan Med J 2008;25:110–6.

Sivapathasundharam B, Kalasagar M. Yet another article on exfoliative cytology. J Oral Maxillofac Pathol. 2004;8:54–7.

Zimmermann ER, Zimmermann AL. Effects of race, age, smoking habits, oral and systemic disease on oral exfoliative cytology. J Dent Res 1965;44:627–31.

Montgomery PW. Study of exfoliative cytology of normal oral mucosa. J Dent res 1951;30:12.

Ogden. Evidence of field change in oral cancer. British journal or oral and maxillofacial surgery 1990;28,390-392.

Ogden GR, Wight AJ. Oral exfoliative cytology. Review method of assessment. J Oral Pathol Med 1997;26,201-5.

Papanicolaou GN, Traut HF. Diagnosis of uterine cancer by the vaginal smear. The commonwealth Fund, New York; 1943.

Bancoczy, J and Rigo, O. Comparative cytologic and histologic studies in oral leukoplakia. J Acta cytological 1976;20,308-12.

Khandelwal S, Solomon MC. Cytomorphological analysis of keratinocytes in oral smears from tobacco users and oral squamous cell carcinoma lesions — A histochemical approach. Int J Oral Sci. 2010;2:45–52.

Henry C, Sandler. Morphological characteristics of malignant cells from mouth lesions. J Acta cytological 1965;9:282-6.

Ordie H, King. The cytology of common and uncommon oral malignancies. J Acta cytologica 1962;6:348-54.

Kumar S, Vezhavendhan N, Priya S. Role of oral exfoliative cytology in oral leukoplakia and squamous cell carcinoma. Int J Clin Dent Sci. 2011;2(1):1.