DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20204229

Cyto-histological correlation in diagnosis of gastrointestinal lesions- a prospective study in a tertiary care institute

Swati Aggarwal, Kavita Mardi, Shivani Sood, Vijay Kaushal, Brij Sharma, Pranav Sood

Abstract


Background: Gastrointestinal tract is involved by a large number of inflammatory, infectious and neoplastic diseases. There is a worldwide rising incidence of GIT lesions especially neoplasms.

Methods: This study was planned to correlate endoscopic and colonoscopic brush cytology with histopathology of gastrointestinal lesions and to determine the spectrum of gastrointestinal lesions in patients subjected to endoscopic brushings and biopsy.

Results: Sensitivity of upper GI brush cytology was 95.15% and specificity 90.41%. Sensitivity of colonoscopic brush cytology was 100% and specificity 86.79%. The accuracy of brush cytology came out to be 92.45% in upper GIT and 92.22% in lower GIT.

Conclusions: Brush cytology is a non-invasive and cost-effective method to retrieve epithelial cells from a much larger surface area of the mucosa, thus allowing thorough sampling and increasing the diagnostic yield.


Keywords


Cytology, Gastrointestinal tract, Neoplasms

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References


Rozen, P. Cancer of the gastrointestinal tract: early detection or early prevention? Eur J Cancer Prevent. 2004;13:71-5.

Geramizadeh B, Shafiee A, Saberfirruzi M, Kumar PK, Shaheem A. Brush cytology of gastric malignancies. Acta Cytol. 2002;46:693-6.

Vidyavathi K, Harendrakumar ML, LakshmanaKumar YC. Correlation of endoscopic brush cytology with biopsy in diagnosis of upper gastrointestinal neoplasms. Indian J Pathol Microbiol. 2008;51:489-92.

Bardawil RG, Ambrosio FGD, Hajdu SI. Colonic cytology a retrospective study with histopathologic correlation. Acta Cytol. 1989;34:620-6.

Bazaz-Malik G, Lal N. Malignant tumours of the digestive tract a twenty five year study. Indian J Pathol Microbiol. 1989;32:179-85.

Sharma P, Misra V, Singh PA, Misra SP, Gupta SC. A correlative study of histology and imprint cytology in the diagnosis of gastrointestinal tract malignancies. Indian J Pathol Microbiol. 1997;40:139-46.

Kalyani R, Das S, Kumar ML. Spectrum of gastro-intestinal cancers- a ten-year study. J Indian Med Assoc. 2010;108(10):659-62.

Lan CS. Critical evaluation of the fibrogastroendoscopic samples obtained under direct vision. Acta Cytol. 1988;34:217-20.

Sayeed MA, Islam R, Siraji D, Hoque MG, Mohsen AQM. Colonoscopy: a study of findings in 332 patients. J Chittagong Med Coll Teachers Assoc. 2007;18:28-31.

Kontzoglou K, Moulakis GM, Alexiou D. The role of liquid based cytology in the investigation of colorectal lesions: a cytohistological correlation and evaluation of diagnostic accuracy. Langerbecks Arch Surg. 2007;392:189-95.

Cook IJ, de Carle DJ, Haneman B, Hunt DR, Talley NA, Miller D. The role of brushing cytology in the diagnosis of gastric malignancy. Acta Cytol. 1988;32:461-4.