Clinical profile of dengue fever infection in patients admitted in tertiary care centre Agroha, Hisar, Haryana, India

Authors

  • Mohd Younus Shah Department of Medicine, Maharaja Agarson Medical College and Hospital, Agroha, Hisar, Haryana
  • Mohd Mubarak Naqash Department of Medicine, Maharaja Agarson Medical College and Hospital, Agroha, Hisar, Haryana
  • R. K. Goel Department of Medicine, Maharaja Agarson Medical College and Hospital, Agroha, Hisar, Haryana
  • Deepak Galhan Department of Medicine, Maharaja Agarson Medical College and Hospital, Agroha, Hisar, Haryana
  • Sunil Kumar Department of Medicine, Maharaja Agarson Medical College and Hospital, Agroha, Hisar, Haryana
  • Vivek Chhabra Department of Medicine, Maharaja Agarson Medical College and Hospital, Agroha, Hisar, Haryana
  • Abhishek Saini Department of Medicine, Maharaja Agarson Medical College and Hospital, Agroha, Hisar, Haryana
  • K. L. Jaggal Department of Medicine, Maharaja Agarson Medical College and Hospital, Agroha, Hisar, Haryana

DOI:

https://doi.org/10.18203/2320-6012.ijrms20161776

Keywords:

Dengue fever, Thrombocytopenia, Leucopoenia

Abstract

Background: Dengue infections can result in a wide spectrum of disease severity ranging from an influenza-like illness (dengue fever; DF) to the life-threatening dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). The study was aimed to compare the clinical profile of all patients diagnosed with dengue viral infection at MAMC.

Methods: This retrospective study included 188 patients infected with dengue virus, age 6 years to 70 years. Laboratory and haematological data were included.

Results: Peak of infection occurred in October 2015 and least number of cases were recorded in December 2015. Common clinical symptoms were fever, and abdominal pain. Common haematological abnormalities were thrombocytopenia and leucopoenia. All patients survived. There was no case of dengue hemorrhagic fever or dengue shock syndrome.

Conclusions: Significant differences in the clinical profile is possibly because of infection with different serotypes of dengue virus (DENV), concurrent/sequential infection of more than one serotype, and differences in host immune responses associated with host genetic variations.

References

WHO Fact sheet No 117: Dengue and dengue haemorrhagic fever. (2008). Available: http://www.who.int/mediacentre/factsheets/fs117/e/.

Dengue and Dengue Hemorrhagic Fever: Information for Health Care Practitioners - CDC Division of Vector-Borne Infectious Diseases. Available:http://www.cdc.gov/ncidod/dvbid/dengue/dengue-hcp.htm.

Malavige GN, Fernando S, Fernando DJ, Seneviratne SL. Dengue viral infections. Postgrad Med J. 2004; 80:588-601.

Khan NA, Azhar EI, El-Fiky S, Madani HH, Abuljadial MA, Ashshi AM, Turkistani AM, Hamouh EA. Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia. Acta Trop. 2008;105:39-44.

Central Department of Statistics & Information, Kingdom of Saudi Arabia. Available: http://www.cdsi.gov.sa/showproductstandard.aspx?lid=26&pid=1005.

Ramos MM, Tomashek KM, Arguello DF, Luxemburger C, Quiñones L, Lang J, Muñoz-Jordan JL. Early clinical features of dengue infection in Puerto Rico. Trans R Soc Trop Med Hyg. 2009;103(9):878-84.

de Oliveira SA, Bastos Camacho LA, Fernandes Bruno L, de Gusmão RC, de Medeiros Pereira AC, Coca Velarde LG, Mendonça Siqueira M. Acute arthropathy in patients with rash diseases: a comparative study. Clin Rheumatol. 2009;28(9):1067-71.

WHO (1997) Dengue haemorrhagic fever: diagnosis, treatment, prevention and control, 2nd edition. Geneva: World Health Organization.

Griffais R, Andre PM, Thibon M K-tuple. Frequency in the human genome and polymerase chain reaction. Nucleic Acid Res. 1991;19:3887-91.

Ayyub M, Khazindar AM, Lubbad EH, Barlas S, Alfi AY, Al-Ukayli S. Characteristics of dengue fever in a large public hospital, Jeddah, Saudi Arabia. J Ayub Med Coll Abbottabad. 2006;18:9-13.

Coffey LL, Mertens E, Brehin AC, Fernandez-Garcia MD, Amara A, Després P, Sakuntabhai A. Human genetic determinants of dengue virus susceptibility. Microbes Infect. 2009;11:143-56.

Balmaseda A, Hammond SN, Pérez L, Tellez Y, Saborío SI, Mercado JC, Cuadra R, Rocha J, Pérez MA, Silva S, Rocha C, Harris E. Serotype-specific differences in clinical manifestations of dengue. Am J Trop Med Hyg. 2006;74:449-56.

Bharaj P, Chahar HS, Pandey A, Diddi K, Dar L, Guleria R. Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India. Virol J. 2008;5:1.

Loroño-Pino MA, Cropp CB, Farfán JA, Vorndam AV, Rodríguez-Angulo EM, Rosado-Paredes EP, Flores-Flores LF, Beaty BJ, Gubler DJ. Common occurrence of concurrent infections by multiple dengue virus serotypes. Am J Trop Med Hyg. 1999;61:725-30.

Zaki A, Perera D, Jahan SS, Cardosa MJ. Phylogeny of dengue viruses circulating in Jeddah, Saudi Arabia: 1994 to 2006. Trop Med Int Health. 2008 13:584-92.

Wilder-Smith A, Gubler DJ. Geographic expansion of dengue: the impact of international travel. Med Clin North Am. 2008; 92:1377-90.

Chaturvedi U, Nagar R, Shrivastava R. Dengue and dengue haemorrhagic fever: implications of host genetics. FEMS Immunol Med Microbiol. 2006;47: 155-66.

Long HT, Hibberd ML, Hien TT, Dung NM, Van Ngoc T, Farrar J, Wills B, Simmons CP. Patterns of gene transcript abundance in the blood of children with severe or uncomplicated dengue highlight differences in disease evolution and host response to dengue virus infection. J Infect Dis. 2009;199:537-46.

Swaminathan S, Khanna N. Dengue: recent advances in biology and current status of translational research. Curr Mol Med. 2009; 9:152-73.

Crill WD, Hughes HR, Delorey MJ, Chang GJ. Humoral immune responses of dengue fever patients using epitope-specific serotype-2 virus-like particle antigens. PLoS ONE 2009;4(4):e4991.

Downloads

Published

2017-01-02

How to Cite

Shah, M. Y., Naqash, M. M., Goel, R. K., Galhan, D., Kumar, S., Chhabra, V., Saini, A., & Jaggal, K. L. (2017). Clinical profile of dengue fever infection in patients admitted in tertiary care centre Agroha, Hisar, Haryana, India. International Journal of Research in Medical Sciences, 4(6), 2146–2149. https://doi.org/10.18203/2320-6012.ijrms20161776

Issue

Section

Original Research Articles