DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20205026

Study of diabetes mellitus among patients with sickle cell disease

Prafulla Kumar Bariha, Biswaranjan Prusty, Manoj Kumar Mohapatra

Abstract


Background: Type 2 diabetes mellitus (T2DM) occurs when impaired insulin effectiveness is accompanied by decreased insulin production by β cells. With 366 million people diagnosed in 2011 and a trend of increasing prevalence worldwide (Lyssenko and Laakso 2013), diabetes is one of the major threats to human health. Objectives of the study were to assess the occurrence of diabetes mellitus in sickle cell disease (SCD) patients and to study glycemic status of patients with SCD and clinical presentation.

Methods: An observational study was done at department of general medicine and sickle cell clinic and molecular biology laboratory, Veer Surendra Sai institute of medical science and research, Burla between November 2014 to October 2016. All recorded data analyzed through standard statistical methods including standard diagram and groups and finding were discussed in detail to draw appropriate conclusion, through standard statistical methods including standard diagrams.

Results: The study was taken on 137 cases of SCD patients admitted at VIMSAR, Burla. Sex distribution of SCD patient with male (68.81%) and female (31.38%) clinical feature of SCD patients shows VOC (vaso occlusive crisis) was the most common presentation for hospital admission followed by fever, anemia, jaundice, AVN (avascular necrosis), osteomyelitis, dactylitis. The most of SCD are having normoglycemic with most of diabetes mellitus are in control group. Glycemic status in SCD cases and controls with 6.57% cases of SCD, 13.14% of controls are hyperglycemic.

Conclusions: The majority of patients in this SCD patients were between the age group 15-20 years. The occurrence of diabetes mellitus in SCD patients is low in compare to control population. Showing impairment of glucose tolerance in SCD but low presence of diabetes mellitus. presence of lower life span of RBC, hypermetabolic state and low body mass index in SCD patients.


Keywords


SCD, VOC, AVN, HPLC, T2DM

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References


Morrison JC, Schneider JM, Kraaus AP, Kitabchi AE. The prevalence of diabetes mellitus in sickle cell haemoglobinopathies. J Clin Endocrinol Metab. 1979;48:192-95.

Barden EM, Kawchak DA, Ohene-Frempong K, Stallings VA, Zemel BS. Body composition in children with sickle cell disease. Am J Clin Nutrition. 2002;76(1):218-25.

Adekile AD, Jegenda AO. Juvenile onset diabetes mellitus in a sickle cell anaemia patient. East Afr Med J. 1990;67:591-3.

Kar BC. Sickle cell disease in India. J Asso Phy Ind. 1991;39:954-60.

Kar BC. Clinical profile of sickle cell trait. J Asso Phy Ind. 2002;50:1368-71.

Balgir RS. Epidemiology, Population health genetics and phenotypic diversity of Sickle cell disease in India. Int J Bio Anthropol. 2007;1(2):1939-4594.

Reid HL. Kaniew: Concurrent sickle cell disease and Diabetes Mellitus. Trop Geoqr Med. 1988;40:201-4.

Serjeant GR. Irreversibly sickle cells and splenomegaly in sickle cell anemia. Br J Haematol. 1970;19:635.

Alayash AI, Al- Quoriam A. Prevalence of diabetes mellitus in individuals heterozygous and homozygous for sickle cell anemia. Clin Physiol Biochem. 1989;7(2):87-92.

Lahousen T, Roller RE, Lipp RW, Schnedl WJ. Silent haemoglobin variants and determination of HbA1c with the HPLC Bio-Rad Variant II. J Clin Pathol. 2002;55(9):699-703.

Radin MS. Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading. J General Int Med. 2014;29(2):388-94.