A study of the correlation of serum vitamin D levels to Child-Pugh and MELD-Na scoring system in cirrhosis of the liver

Authors

  • Jitendra Kumar Patel Department of Medicine, RNT Medical College, Udaipur, Rajasthan, India
  • Hemant Kumar Mahur Department of Medicine, RNT Medical College, Udaipur, Rajasthan, India
  • Shaitan Singh Jat Department of Medicine, RNT Medical College, Udaipur, Rajasthan, India
  • D. P. Singh Department of Medicine, RNT Medical College, Udaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20205846

Keywords:

MELD score, CLD, Vitamin D, Child-Pugh score

Abstract

Background: Vitamin D is a hormone with known effect on calcium homeostasis, but recently there is increasing recognition that it also is involved in cell proliferation and differentiation, has immunomodulatory and anti-inflammatory properties. These effect may explain its importance in the liver diseases. Vitamin D deficiency has been reported highly prevalent in Chronic liver disease (CLD) and there is an emerging interest to explore the relationship of vitamin D deficiency and severity of CLD. The aim of the study was to evaluate the correlation of serum vitamin D levels to the Child Pugh and MELD-Na scoring system in liver cirrhosis and to establish its relationship with the severity of the disease.

Methods: Serum vitamin D levels were measured in 100 patients of CLD and 100 healthy controls. The degree of liver dysfunction was estimated by Child-Pugh and MELD-Na scores.

Results: 91% of the CLD patients had subnormal vitamin-D levels. The mean vitamin D level in CLD patients was lower (15.97±7.45) than controls (30.12±6.60) with statistical significance (p= 0.0001). On linear regression vitamin D level showed significant negative correlation with Child Pugh score (r= –0.446, p<0.001) and MELD score (r= –0.395, p<0.001). Low vitamin D level was associated with poor outcome (mean vitamin D level 9.61±3.01 who died versus 16.52±7.47 who survived and discharged).

Conclusions: CLD is associated with a significantly low level of vitamin D. The lower level of vitamin D is associated with severity of CLD, mortality and increased risk for complications. Awareness of serum vitamin D level in CLD patients is important to improve outcome.

Author Biographies

Jitendra Kumar Patel, Department of Medicine, RNT Medical College, Udaipur, Rajasthan, India

Resident, Department of Medicine

Hemant Kumar Mahur, Department of Medicine, RNT Medical College, Udaipur, Rajasthan, India

Professor, Department of Medicine,

Shaitan Singh Jat, Department of Medicine, RNT Medical College, Udaipur, Rajasthan, India

Resident, Department of Medicine

D. P. Singh, Department of Medicine, RNT Medical College, Udaipur, Rajasthan, India

Sr. Professor & Head, Department of Medicine

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Published

2020-12-28

How to Cite

Patel, J. K., Mahur, H. K., Jat, S. S., & Singh, D. P. (2020). A study of the correlation of serum vitamin D levels to Child-Pugh and MELD-Na scoring system in cirrhosis of the liver. International Journal of Research in Medical Sciences, 9(1), 210–215. https://doi.org/10.18203/2320-6012.ijrms20205846

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Original Research Articles