DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20205458

Prevalence of tuberculosis in silicosis patients in southern part of Rajasthan

Atul Luhadia, Shanti Kumar Luhadia, Rahul Ahluwalia, Kamal Preet Singh Arora, Rahul Kumar, Trishi Nagda, Adit Zota

Abstract


Background: Silicosis is an occupational lung disease which commonly occurs in workers involved in quarrying, mining, sandblasting etc. Tuberculosis (TB) in silicosis is more common. In southern part of Rajasthan, near Udaipur a lot of mining areas are there and workers are exposed to silica dust. The main objective of carrying out this study is to bring in focus the increasing prevalence of silicosis patients and its complications in mining areas around Udaipur in southern Rajasthan, so that the necessary prophylactic and preventive measures can be taken for the workers in future.

Methods: 150 patients of silicosis and old treated case of silicotuberculosis patient with respiratory symptoms were included in the study. In all the patients, sputum was sent for routine acid fast bacilli (AFB) smear examination and if it came negative then sputum was sent for GeneXpert multidrug resistant tuberculosis (MTB) and also for AFB culture examination wherever needed.

Results: The mean duration of exposure to silica particles was 10 years (5 to 15 years). Tuberculosis was diagnosed by microbiological examination in 40 cases, while 25 cases which were previously treated for tuberculosis were found negative on microbiological examination. So, the overall prevalence of TB (both old treated and new or relapse microbiologically confirmed cases) among patients of silicosis was found to be 44%.

Conclusions: Our study showed an increased prevalence of tuberculosis in silicosis patients. So, there should be regular health check up educational programme for all silica mines workers and all should use prophylactic measures.  


Keywords


Silicosis, Silicotuberculosis, Silica dust, Southern Rajasthan, Sputum

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References


International Labour office. Encyclopedia of Occupational Health and Safety, 4th edn. Geneva: International Labour office. 1997.

National Institute for Occupational safety and Health. The work-related Lung Disease Surveillance report, 2002. Cincinnatti, OH: NIOSH. 2003.

American Thoracic Society. Adverse effects of crystalline silica exposure. Am J Respir Crit Care Med. 1997;155:761-68.

Cullinan P, Reid P. Pneumoconiosis. Prim Care Respir J. 2013;22(2):249-52.

Gupta A. Silicosis – an uncommonly diagnosed common occupational disease. Icmr bull. 1999;29(9):1-7.

Banks DE, Cheng YH, Weber SL, Ma JK. Strategies for the treatment of pneumoconiosis. Occup Med. 1993;8:205-32.

Barboza CE, Winter DH, Seiscento M, Santos UP, Terra FM. Tuberculosis and silicosis: epidemiology, diagnosis and chemoprophylaxix. J Bras Pneumol. 2008;34(11):959-66.

Global tuberculosis report. 2019. WHO website-http://www.who.int>tb>global_report. Accessed on 20 October, 2020.

TB INDIA 2019 – ANNUAL STATUS REPORT. https://tbcindia.gov.in. Accessed on 20 October, 2020.

Snider DE. Relationship between tuberculosis and silicosis(editorial). Am Rev Respir Dis. 1978;118:455-60.

Sherson D, Lander F. Morbidity of pulmonary tuberculosis among silicotic and non-silicotic foundry workers in Denmark. J Occup Med. 1990;32:110-3.

Chen GX, Burnett CA, Cameron LL, Alterman T, Lalich NR, Tanaka S, et al. Tuberculosis mortality and silica exposure: A case- control study based on a national mortality database for the years 1983-1992. Int J Occup Environ Health. 1997;3(3):163-70.

Iyer R,Holian A. Immunological aspects of silicosis. In: Castranova V, wallyathan V, Wallace E,eds. Silca and silica-induced lung diseases. Boca Raton: CRC Press. 1996;253-267.

Allison AC, Hart PD. Potentiation by silica of the growth of mycobacterium tuberculosis in macrophage cultures. Br J Exp pathol. 1968;49(5):465-76.

Cowie RL. The epidemiology of tuberculosis in gold miners with silicosis. Am J Respir Crit Care Med. 1994;150:1460-2.

Churchyard GJ, Corbett EL. Tuberculosis and associated diseases. In: Handbook of Occupational Health Practice in the South African Mining Industry. Johannesburg: SIMRAC. 2001;153-192.

Hnizdo E, Murray J. Risk of pulmonary tuberculosis relative to silicosis and exposure to silica dust in South African gold miners. Occup Environ Med. 1998;55:496-502.

Corbett EL, Churchyard GJ, Clayton TC, Williams BG, Mulder D, Hayes RJ, et al. HIV infection and silicosis: the impact of two potent risk factors on the incidence of mycobacterial disease in South African miners. AIDS. 2000;14(17):2759-68.

Hessel PA, Gamble JF, Nicolich M. Relationship between silicosis and smoking. Scand J Work Environ Health. 2003;29(5):329-36.

Sikand BK, Pamra SP. Preliminary Report on the occurrence of silicosis among stone masons, proceedings of 7th tuberculosis workers. Ind J Chest Dis. 1964;6(1):37-38.

Chopra K, Prakash P, Bhansali S, Mathur A, Gupta P. Incidence and prevalence of silicotuberculosis in Western Rajasthan : A retrospective study of three years. National Journal of Community Medicine. 2012;3(1).