The prevalence of gastroesophageal reflux disease and its association with various risk factors in a tertiary care centre in West Bengal

Authors

  • Anant Parasher Department of Medicine, Guru Teg Bahadur Hospital, New Delhi, India
  • Kunal Ranjan Department of Medicine, Guru Teg Bahadur Hospital, New Delhi, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20210877

Keywords:

Gastroesophageal reflux disease, Heartburn, Regurgitation

Abstract

Background: Gastroesophageal Reflux (GER) is the regurgitation of gastric contents and acid into the esophagus. Frequent and abnormal amounts of reflux leads to Gastroesophageal reflux disease (GERD) which causes symptoms like heartburn, regurgitation, and /or other complications. In view of absence of any data on the prevalence of GERD from this part of India, the current population based study was conducted to study the prevalence of GERD and its association with various risk factors.

Methods: In this community based prospective cross-sectional observational study, 500 patients from rural and urban areas of West Bengal were included during the one year period from July 2014 to June 2015.

Results: Out of a total of 500 patients studied, the percentage of patients with GERD in our study population was found to be 31.3%. Out of 292 males enrolled for the study, number of patients with GERD was 66 (22.6%) as compare to females where the same was found to be 43.26% (90/208). The majority (68.2%) of patients had mild GERD, 18.5% had moderate GERD whereas only 13.3% of patients had severe GERD.

Conclusions: The percentage of patients with GERD in our study population was found to be 31.3%. It was observed to be significantly associated with increasing Body Mass Index (B.M.I), smoking, the female gender, a sedentary lifestyle, dinner to bed-time interval of ≤2 hours, chronic NSAID use, and a past history of abdominal surgery.

References

Jo SJ, Kim N, Lim JH, Shin CM, Park YS, Lee DH et al. Comparison of gastroesophageal reflux disease symptoms and proton pump inhibitor response using gastroesophageal reflux disease impact scale questionnaire. J Neurogastroenterol Motil. 2013;19:61-9.

Vaezi MF. Gastroesophageal reflux disease: A gastroenterologist’s perspective. Perspectives on voice and voice disorders. J Neurogastroenterol Motil. 2011;21:89-99.

Mahadeva S, Raman MC, Ford AC, Follows M, Axon AT, Goh KL, et al. Gastro-esopha­geal reflux is more prevalent in Western patients with dyspepsia. Aliment Pharmacol Ther. 2005;21:1483-90.

Hansen JM, Christensen WM, Muckadell OB. Gastroesophageal reflux symptoms in a Danish population: a pro­spective follow-up analysis of symptoms, quality of life, and health-care use. Am J Gastroenterol. 2009;104:2394-2403.

Kumar S, Sharma S, Norboo T, Dolma D, Norboo A, Stobdan T, et al. Population based study to assess prevalence and risk factors of gastroesophageal reflux disease in a high altitude area. Indian J Gastroenterol. 2011;30:135-43.

Locke GR, Talley NJ, Zinsminster AR, Melton LJ. Prevalence and clinical spectrum of gastroesophageal reflux; a population based study in Olmestead County. Gastroenterology. 1997;112:1448-56.

Moshkowitz M, Horowitz N, Halpern Z, Santo E. Gastroesophageal reflux disease symptoms: Prevalence, socio-demographics and treatment patterns in the adult Israeli population. World J Gastroenterol. 2011;17(10):1332-5.

Chen J, Wang H. Prevalence and determinants of gastroesophageal reflux symptoms in adolescents. J Gastroenterol Hepatol. 2014;29(2):269-75.

Kim N, Lee SW, Cho SI. The prevalence of and risk factors for erosive esophagitis prospective study in Korea. Aliment Pharmacol Ther. 2008;27:173-85.

Cho YS, Choi MG, Jeong JJ, Chung WC, Lee IS, Kim SW, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asansi, Korea. Am J Gastroenterol. 2005;100(4):747-53.

Filho JP, Chinzon D, Eisig JN, Hashimoto CL, Zaterka S. Prevalence of heartburn and gastroesophageal reflux disease in the urban Brazilian population. Arq Gastroenterol. 2005;42(2):122-7.

Lazebnik LB, Masharova AA, Bordin DS, Vasil'ev IuV, Tkachenko EI, Abdulkhakov RA, et al. Multicenter study epidemiology of gastroesophageal reflux disease in Russia MEGRE): first results. Eksp Klin Gastroenterol. 2009;6:4-12.

Somi MH, Farhang S, Mirinezhad K, Jazayeri E, Moghaddam S, Moayeri S, et al. Prevalence and precipitating factors of gastroesophageal reflux disease in a young population of Tabriz, Northwest of Iran. Saudi Med J. 2006;27(12):1878-81.

Sharma PK, Ahuja V, Madan K. Prevalence, severity, and risk factors of symptomatic gastroesophageal reflux disease among employees of a large hospital in Northern India. Indian J Gastroenterol. 2011;30(3):128-34.

Wang J, Luo J, Dong L, Gung J, Tong M. Epidemiology of gastroesophageal reflux disease: a general population-based study in Xi’an of Northwest China. World J Gastroenterol. 2004;10(11):1647-51.

Rubio DM, Olaso MEC, Rey E, Locke GR. Symptoms of gastroesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population. Aliment Pharmacol Ther. 2004;19:95-105.

Kamal A. Risk factors and prescription patterns of gastroesophageal reflux disease: HEAL study in Pakistan. World J Gastroenterol. 2014;64:7.

Hung LJ, Yang CY, Wang EM, Lai KH. Prevalence of gastroesophageal reflux disease in general population in Taiwan. J Gastroenterol Hepatol. 2011;8:87-92.

Serag HB, Kvapil P, Bitar HJ. Abdominal obesity and the risk of Barrett's esophagus. Am J Gastroenterol. 2005;100:2151-6.

He J, Xiuqiang E. A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the systematic investigation of gastrointestinal diseases in China. BMC Gastroenterol. 2010;65:1471-82.

Chen T, Lu M, Wang X, Yang Y, Zhang J, Jin L, et al. Prevalence and risk factors of gastroesophageal reflux symptoms in Chinese retiree cohort. BMC Gastroenterol. 2012;12:161.

Pandeya N, Green AC, Whiteman DC. Australian cancer study. prevalence and determinants of frequent gastroesophageal reflux symptoms in the Australian community. Dis Esophagus. 2012;25(7):573-83.

Yonem O, Sivri B, Ozdemir L, Nadir I, Yuksel S, Uygun Y. Gastroesophageal reflux disease prevalence in the city of Sivas. Turk J Gastroenterol. 2013;24:303-10.

Cela L. Lifestyle characteristics and gastroesophageal reflux disease: a population-based study in Albania. Gastroenterol Res Prac. 2013;936792.

Cameron AJ, Lagergren J, Henriksson C. Gastroesophageal reflux disease in monozygotic and dizygotic twins. Gastroenterol. 2002;122:55-9.

Nocon M, Labenz J, Willich SN. Life style factors and symptoms of gastroesophageal reflux- a population based study. Aliment Pharmacol Ther. 2006;23:169-74.

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Published

2021-02-25

How to Cite

Parasher, A., & Ranjan, K. (2021). The prevalence of gastroesophageal reflux disease and its association with various risk factors in a tertiary care centre in West Bengal. International Journal of Research in Medical Sciences, 9(3), 780–785. https://doi.org/10.18203/2320-6012.ijrms20210877

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Original Research Articles