DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161822

Adverse blood transfusion reactions at tertiary care hospital

Surekha K. Chavan, Gorakhnath Patil, Pallavi Rajopadhye

Abstract


Background: The goal of hemovigilance is to increase the safety and quality of blood transfusion. It is necessary to recognize and prompt response to adverse transfusion reactions, which will help in taking appropriate steps to reduce their incidence and make blood transfusion process as safe as possible. The aim of the study was to determine the frequency and type of transfusion reactions (TRs) occurring in patients, reported to the blood bank at our institute.

Methods: A retrospective review of all TRs reported to the blood bank Krishna Hospital, between January 2011 and July 2013 was done. All the TRs were evaluated in the blood bank and classified using standard definitions.

Results: During the study period a total 13126 units of blood and components were issued by our blood bank and total of 45 (0.3%) adverse reactions were reported to blood bank. The most common reaction observed was allergic reaction 25(55.6%) followed by FNHTR 15 (33.3%).

Conclusions: Not a single case of anaphylactic reactions, TRALI, acute immune hemolytic transfusion reaction, and Sepsis was observed. This can be an underestimation of the true incidence because of under reporting which can be improved by proper hemovigilence system to provide better patient care.

 


Keywords


Adverse transfusion reaction, FNHTR, Hemovigilance, Haemolytic transfusion reaction

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References


Training Module For Laboratory Technologists: NACO:1995.

Introduction To Transfusion Medicine: Zarin Bharucha: First Edition 1990.

Bisht, Shing S, Marwaha N. Hemovigilence Programm- India. Asian J Transfus Sci. 2013;7:73-4.

Transfusion Medicine Technical Manual:Saran R.K.: Second Edition 2003.

Mazzei CA, Popovsky MA, Kopko PM. Noninfectious complications of blood transfusion. In: Roback JD, Combs MR, Grossman BJ, Hillyer CD, editors.Technical Manual. 16 th ed. Maryland: American Association of Blood Banks; 2008 p.715-51.

Narvios AB, Lichtiger B, Neumann JL. Underreporting of minor transfusion reactions in cancer patients. Med Gen Med. 2004;6:17.

Bhattacharya P, Marwaha N, Dhawan HK, Roy P, Sharma RR. Transfusion-related adverse events at the tertiary care center in North India: An institutional hemovigilance effort. Asian J Transfus Sci. 2011;5:164-70.

Kumar P, Thapliyal R, Coshic P, Chatterjee K. Retrospective evaluation of adverse transfusion reactions following blood product transfusion from a tertiary care hospital: A preliminary step towards Hemovigilance. Asian J Transfus Sci. 2013;7:109-15.

Moore S, Taswell HF, Pineda AA. Delayed hemolytic transfusion reactions: Evidence of the need for an improved pretransfusion compatibility test. Am J Clin Path. 1980;74:94-7.

Lichtiger B, Thornton E. Hemolytic transfusion reactions in oncology patients: Experience in a large cancer center. J Clin Oncol. 1984;2:438-42.

Robillard P, Itaj kN. Incidence of adverse transfusion reactions in the Quebec Hemovigilance System. Vox Sang. 2002;83:120 (abstr suppl).

Moore SB. Anaphylactic transfusion reactions - A concise review. Ir Med J. 1985;78:54-6.

Ulhman EJ, Isgrigs E, Wallhermanfechtel M, Goodnough LT. Prestorage universal WBC reduction of RBC units does not affect the incidence of transfusion reactions. Transfusion. 2001;41:997-1000.

Kleinman S, Chan P, Robillard P. Risks associated with transfusion of cellular blood components in Canada. Transfus Med Rev. 2003;17:120-62.

Heddle NM, Klama LN, Griffith L, Roberts R, Shukla G, Kelton JG. A prospective study to identify the risk factors associated with acute reactions to platelet and red cell transfusions. Transfusion. 1993;33:794-7.

Kathryn E, Webert, Blajchman MA. Transfusion-related acute lung injury. Transfusion Med Rev. 2003;17:252-62.

Federowicz I, Barrett BB, Andersen JW, Urashima M, Popovsky MA, Anderson KC. Characterization of reactions after transfusion of cellular blood components that are white cell reduced before storage. Transfusion. 1996;36:21-8.