DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20211361

Spectrum of pigmented lesions of skin: a retrospective study in a tertiary health care of Southern Assam

S. K. Abdullah Ahmed, Sania Sultana Ullah, Karishma Bhuyan, Monoj K. Deka, Shah Alam Sheikh

Abstract


Background: Pigmented lesions are one of the most common cause for dermatological consultation.  Most of them are benign, while a majority of them have malignant transformation and are called as melanoma. A careful histopathological interpretation by the pathologist is needed in the diagnosis and management of these lesions. Aims and objectives of the study were- 1. To study the spectrum of various pigmented skin lesions.  2.  To establish the correlation between the microscopic pathological findings of various skin lesions with the presenting clinical features.

Methods: A 3-year study was conducted in the pathology department of tertiary care centre on all skin biopsy tissue which came as pigmented lesion. The entire skin biopsy is submitted for routine processing and embedded in paraffin wax. 3-5 mm thick paraffin sections of the skin biopsy are stained with H and E.

Results: Out of 432 skin biopsies studied during this period, 58 cases were diagnosed as pigmented skin lesions. Of these, the biopsy tissue was inadequate in 5 cases while five cases presented with non-specific findings. Of the remaining cases, 15 were malignant and 33 were benign lesions. Only 18 of these were of melanocytic origin with 8 cases of malignant melanoma and 10 nevi. In the present study an analysis of the clinical diagnosis with the histopathological diagnosis revealed a positive correlation in 54% cases.

Conclusions: A good clinical correlation and biopsy with histopathological diagnosis is necessary for the accurate diagnosis and definite treatment of patients with pigmented skin lesions.


Keywords


Pigmented lesions, Benign, Malignant, Histopathology

Full Text:

PDF

References


Laishram RS, Myrthong BG, Laishram S, Shimray R, Kumar A, Sharma DC. Pigmented skin lesions: are they all of melanocytic origin? A histopathological perspective. J Pak Asso Dermatols. 2013;23:3.

Prasad RJ, Suryakala C, Arfathunnisa M. Clinicopathological study of pigmented skin lesions. J. Evid. Based Med. Healthc. 2020;7(7), 337-41.

Suvernakar SV, Harwani SR, Deshpande SA. Clinicopathological Study of Pigmented Skin Lesions. J Dental Med Sci. 2014;13(5):70-3.

Crasta J, Rameshkumar K. Pigmented lesions of Nonmelanocytic Origin-A Pathological Perspective. Indian J Dermatol. 2002;47(2).

Curley RK, Cook MG, Fallowfield ME, Marsden RA. Accuracy in clinically evaluating pigmented lesions. Bri Med J. 1989;299:16.

Mruthyunjayappa S, Mahantappa H, Gopal MG, Venugopal SB. A study of spectrum of histopathological features in patients presenting with hyperpigmented skin lesions. Arch Med Health Sci. 2016;4:189-95.

MacKie RM, English J, Aitchison TC, Fitzsimons CP, Wilson P. The number and distribution of benign pigmented moles (melanocytic naevi) in a healthy British population. Bri J Dermatol. 1985;113(2):167-74.

Youl PH, Janda M, Aitken JF, Del Mar CB, Whiteman DC, Baade PD. Body‐site distribution of skin cancer, pre‐malignant and common benign pigmented lesions excised in general practice. Brit J Dermatol. 2011;165(1):35-43.

Lens MB, Dawes M. Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma. Brit J Dermatol. 2004;150(2):179-85.

Kukita A, Ishihara K. Clinical features and distribution of malignant melanoma and pigmented nevi on the soles of the feet in Japan. J Investigative Dermatol. 1989;92(5):S210-3.

Rubegni P, Cevenini G, Burroni M. Automated diagnosis of pigmented skin lesions. Int J Cancer. 2002;101:576-80.

Jackson JM, Andrew A, Brian B, Diane SB, Susan T, Jonathan SW. Current Understanding of Seborrheic Keratosis: Prevalence, Etiology, Clinical Presentation, Diagnosis, and Management. J Drugs Dermatol. 2015;14(10):1119-25.

Wanebo HJ, Cooper PH, Young DV. Prognostic factors in head and neck melanoma. Effect of lesion location. Cancer. 1988;62:831-7.

Walter MF, Morris HC, Humphreys E. Protocol for the Mole Mate UK Trial: a randomised controlled trial of the Mole Mate system in the management of pigmented skin lesions in primary care. BMC Fam Pract. 2010; 11(36).

McGrath JA, Uitto J. Anatomy and organization of skin. In Burns DA, editor. Rooks Text Book of Dermatology. 8th ed. London: Blackwell Publishers; 2010;1:3.1-3.5.