Microbiological profile of COVID-19 patients admitted in a tertiary care hospital Mathura, Uttar Pradesh, India

Authors

  • Anju Rani Department of Microbiology, KD Medical College and Research Centre, Mathura, Uttar Pradesh, India
  • Varuna Gupta Department of Microbiology, KD Medical College and Research Centre, Mathura, Uttar Pradesh, India
  • Kandhakumari Gandhi Department of Microbiology, KD Medical College and Research Centre, Mathura, Uttar Pradesh, India
  • Ashok Kumar Dhanvijay Department of Microbiology, KD Medical College and Research Centre, Mathura, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20211876

Keywords:

COVID-19, Co-infection, SARS-CoV-2, CRP

Abstract

Background: The pandemic due to severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) has drawn worldwide worst effect with diagnostic challenge. Every investigation has its own importance for diagnosis, care, treatment and for management of corona virus disease-2019 (COVID-19) patients. Here this prospective study aimed to investigate the microbiological profile, prevalence of co-infection, and antibiotic susceptibility pattern of patients with confirmed SARS-CoV-2.

Methods: A total of 336 samples were processed in COVID laboratory, Department of Microbiology. An array of serological investigations was done by rapid card screening test. C-Reactive protein (CRP) was analyzed by nephelometer. Blood culture was done by automated system and urine culture on Cystine-Lactose-Electrolyte-Deficient (CLED) Agar. Antibiotic susceptibility tests were done by Kirby Bauer disc diffusion method.

Results: Out of 336 samples tested 76%were male and 24%were female. All samples tested were negative for HIV, HBsAg, HCV, syphilis, malarial parasite. CRP and Typhi -dot with IgM and IgG antibody were positive in 89.28% and 11.42% respectively. About 27% of COVID-19 patients showed bacterial and fungal co-infections. The most prevalent organisms were MR-CoNS (26%), K. pneumoniae (19%) and less prevalent were P. aeruginosa (6%) and A. baumannii (4%).  C. albicans (11%) was the only isolated fungi. All gram positive isolates were 100% sensitive to Linezolid and vancomycin, among gram negative isolates, 100% were sensitive to colistin and polymyxin B.

Conclusions: Microbiological investigation for presence of other co-infecting agents among patients with COVID-19 infection should be considered, and prompt treatment should be carried out accordingly.

Author Biographies

Anju Rani, Department of Microbiology, KD Medical College and Research Centre, Mathura, Uttar Pradesh, India

Assistant Professor, Dept. of Microbiology, K.D Medical Hospital and Research Center, Mathura, Uttar Pradesh, India -281406

Varuna Gupta, Department of Microbiology, KD Medical College and Research Centre, Mathura, Uttar Pradesh, India

Assistant Professor, Dept. of Microbiology, K.D Medical Hospital and Research Center, Mathura, Uttar Pradesh, India -281406

Ashok Kumar Dhanvijay, Department of Microbiology, KD Medical College and Research Centre, Mathura, Uttar Pradesh, India

Director and HOD, Dept. of Microbiology, K.D Medical Hospital and Research Center, Mathura, Uttar Pradesh, India -281406

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Published

2021-04-28

How to Cite

Rani, A., Gupta, V., Gandhi, K., & Dhanvijay, A. K. (2021). Microbiological profile of COVID-19 patients admitted in a tertiary care hospital Mathura, Uttar Pradesh, India. International Journal of Research in Medical Sciences, 9(5), 1403–1407. https://doi.org/10.18203/2320-6012.ijrms20211876

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Original Research Articles