Study on baseline characteristics and lipid profile abnormalities among type 2 diabetic patients attending urban diabetic care hospital, Bangladesh

Authors

  • Shajedul Islam Department of Biochemistry, TMSS Medical College, Bogura, Rajshahi, Bangladesh
  • Ariful Islam Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
  • Wasim Bari Department of Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh
  • Ariful Islam Department of Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh
  • Sifat Ul Islam Department of Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh
  • Mohammad Amirul Islam Department of Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh

DOI:

https://doi.org/10.18203/2320-6012.ijrms20212217

Keywords:

Glycated hemoglobin, Fasting blood sugar, Type 2 diabetes mellitus, Dyslipidemia, Systolic blood pressure, Diastolic blood pressure

Abstract

Background: Altered levels of serum glycated hemoglobin (HbA1c) and lipid profile are prevalent in patients having type 2 diabetic mellitus (T2DM). Aim of the study was to investigate the relationship between serum HbA1c and lipid profile in T2DM to predict diabetic dyslipidemia.

Methods: A structured questionnaire was filled up by each study subject to collect data according to study protocol including age, gender, BMI, BP, residential status, socio-economic status, educational status, physical activity, dietary habit, smoking and duration of diabetes. We collected blood samples from 270 type-2 diabetes mellitus (T2DM) patients aged 30-65 years after overnight fasting (10-12 hours). Then blood samples collected from T2DM patients were used to measure serum levels of HbA1c, fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were estimated by standard laboratory methods.

Results: In this study, increased levels of fasting blood glucose (8.61 mmo/l), HbA1c (7.86%), TC (226.15 mg/dl), TG (193.34 mg/dl) and LDL (147.37 mg/dl), and decreased levels of HDL (40.36 mg/dl) were observed in T2DM patients. Moreover, the strong positive correlation of HbA1c levels with FBG, TC, TG, and LDL levels were found in this study. Besides, a very strong and significant negative correlation (R2=0.1822) between the serum levels of HbA1c and HDL were noted in this study.

Conclusions: This study revealed a strong correlation between dyslipidemia and serum levels of HbA1c in T2DM patients.

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Published

2021-05-27

How to Cite

Islam, S., Islam, A., Bari, W., Islam, A., Islam, S. U., & Islam, M. A. (2021). Study on baseline characteristics and lipid profile abnormalities among type 2 diabetic patients attending urban diabetic care hospital, Bangladesh. International Journal of Research in Medical Sciences, 9(6), 1523–1531. https://doi.org/10.18203/2320-6012.ijrms20212217

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Original Research Articles