DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20211439

A study on prevalence of various mood disorders in patients with multiple sclerosis in South Indian population Chennai, Tamil Nadu

Sivaji Murugaiyan, Akshaya Rathin Sivaji, A. Marian Jude Vijay, Indumathi Sundaramurthi, Jawahar Marimuthu

Abstract


Background: The prevalence of depressive disorders are more common in demyelination diseases like multiple sclerosis. Patients with multiple sclerosis have higher rates of depressive episodes than the general population. It is found that 40-50% incidence reported in many number of previous research studies .The aim is to study the prevalence of various depressive disorders in multiple sclerosis (MS) patient population.

Methods: 176 MS patients were randomly selected from neurology outpatient department (OPD) of Tamil Nadu Government Multi Super Specialty Hospital and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, from September 2018 to December 2019. 128 patients were analyzed with the following methods of examinations such as the structured psychiatric clinical interview with diagnostic and statistical manual of mental disorders (DSM)-5 and international classification of diseases (ICD)-10 criteria, Hamilton depression rating scale (HAM-D) scale.

Results: Various subtypes of mood disorders were found as follows major depressive disorder (MDD)-4%, MDD with anxiety-6%, pervasive developmental disorders (PDD) mixed-4%, premenstrual dysphoric disorder (PMDD)-8%, MIDD-2% and depressive disorders due to general medical conditions (secondary depression)-22%. In this present study 46% of the MS population were diagnosed with various depressive illness.

Conclusions: Early identification and treatment of depressive disorders definitely favour the outcome of MS patients. The coping skills and good social support system play a vital role in the outcome of depressive disorders in MS population in addition to psychopharmacological management.

 


Keywords


Multiple sclerosis, Depressive disorder, HAM-D scales

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References


Feinstein A, Magalhaes S, Richard JF, Audet B, Moore C. The link between multiple sclerosis and depression. Nat Rev Neurol. 2014;10(9):507-17.

Cetin K, Johnson KL, Ehde DM, Kuehn CM, Amtmann D, Kraft GH. Antidepressant use in multiple sclerosis: epidemiologic study of a large community sample. Multiple Sclerosis. 2007;13(8):1046-53.

Rickards H. Depression in neurological disorders: Parkinson's disease, multiple sclerosis and stroke. J Neurol Neurosurg Psychiatr. 2005;76:48-52.

Patten SB, Beck CA, Williams JVA. Major depression in multiple sclerosis: a population-based perspective. Neurology. 2003;61:1524-7.

Sadovnick AD, Remick RA, Allen J. Depression and multiple sclerosis. Neurology. 1996;46:628-32.

Guedes APT. Prevalence of depression in multiple sclerosis. Dissertation- Salvador. Neuro-Psiquiatr. 2011;69(2b).

Alsaadi T, El Hammasi K, Shahrour TM, Shakra M, Turkawi L, Mudhafar A, et al. Prevalence of Depression and Anxiety among Patients with Multiple Sclerosis Attending the MS Clinic at Sheikh Khalifa Medical City, UAE: Cross-Sectional Study. Multiple Sclerosis Int. 2015;487159.

Boeschoten RE, Braamse AMJ, Beekman ATF, Cuijpers P, van Oppen P, Dekker J, Uitdehaag BMJ. Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis. J Neurol Sci. 2017;372:331-41.

Magyari M, Sorensen PS. Comorbidity in Multiple Sclerosis. Front Neurol. 2020;11:851.

Karimi S, Andayeshgar B, Khatony A. Prevalence of anxiety, depression, and stress in patients with multiple sclerosis in Kermanshah-Iran: a cross-sectional study. BMC Psychiatr. 2020;20:166.

Kessler RC, Mc Gonagle KA, Shao S, Nelson CB. Lifetime and 12-month prevalence of DSM-III-R Psychiatric disorders in the United States: Results from the national co-morbidity study. Arch Gen Psychiatr.1994;51(1):8-19.

Kovacs M, Obrosky D, Sherrill J. Developmental changes in the phenomenology of depression in girls compared to boys from childhood onward. J Affect Disord. 2003;74:33-48.

Simpson HB, Nee JC, Endicott J. First-episode major depression. Arch Gen Psychiatr. 1997;54:633-9.

Depression Definition and DSM-5 Diagnostic Criteria. Available at: https://www.psycom.net/ depression-definition-dsm-5-diagnostic-criteria/. Accessed on 24 January 2021.

Gilberthorpe TG, EO’Connell K, Carolan A, Silber E, Brex PA, Sibtain NA, DavidAS. The spectrum of psychosis in multiple sclerosis: a clinical case series; Neuropsychiatr Dis Treat. 2017;13:303-18.

Schiffer RB. Disturbances of affect. In: Rao SM, ed. Neurobehavioral aspects of multiple sclerosis. New York: Oxford University Press. 1990.

Minden SL, Orav J, Reich P. Depression in multiple sclerosis. Gen Hosp Psychiatr. 1987;9:426-34.

Joffe RT, Lippert GP, Gray TA. Mood disorder and multiple sclerosis. Arch Neurol. 1987;44:376-8.

Chwastiak L, Ehde DM, Gibbons LE. Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample. Am J Psychiatr. 2002;159:1862-8.

Pakenham KI. Adjustment to multiple sclerosis: application of a stress and coping model. Health Psychol. 1999;18:383-92.

Siegert RJ, Abernethy DA. Depression in multiple sclerosis: a review. J Neurol Neurosurg Psychiatr. 2005;76:469-75.

Mohr DC, Goodkin DE. Treatment of depression in multiple sclerosis. Clin Psychol Sci Pract. 1999;6:1-9.

Pérez LP, González RS, Lázaro EB. Treatment of mood disorders in multiple sclerosis. Curr Treat Options Neurol. 2015;17(1):323.

Barnhorst A. The empty promise of suicide prevention. New York Times, April 26, 2019. Available at: https://www.nytimes.com/2019/04/ 26/opinion/sunday/suicide-prevention.html. Accessed on 24 January 2021.

Solaro C, Gamberini G, Masuccio FG. Depression in Multiple Sclerosis: Epidemiology, Aetiology, Diagnosis and Treatment, CNS Drugs. 2018;32:117-33.