DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20214422

Histopathological study of soft tissue tumours in a tertiary health centre in southern part of Assam

Khadija S. Tapadar, Manoj K. Deka, R. N. Chaubey, Shah A. Sheikh, Gargi R. Choudhury, Madhusmita Choudhury

Abstract


Background: Soft tissue tumors are defined as mesenchymal proliferations which occur in the extraskeletal non-epithelial tissues of the body, excluding the viscera, coverings of brain and   lymphoreticular system. The objective of this study was to study the histopathological features of soft tissue tumors and to study the occurrence of soft tissue tumors in relation to age, sex and anatomical site.

Methods: This study comprised of 89 cases studied over a period of two years. All soft tissue tumors, their gross features, microscopic findings were analysed in detail. Soft tissue tumors were divided into benign and malignant categories and further sub typing were done according to World Health Organization (WHO) classification. The distribution of soft tissue tumors according to the age, sex and site of occurrence was studied.

Results: Out of 89 cases of soft tissue tumors, 76 cases were benign, 4 cases belonged to intermediate category and 9 cases were malignant. Adipocytic tumors formed the largest group constituting 39 cases. Vascular tumors were the second commonest (26 cases) followed by peripheral nerve sheath tumors (11 cases). The benign tumors were seen in younger age as compared to malignant tumors. Malignant soft tissue tumors was seen to be more common in male than female and pleomorphic sarcoma and liposarcoma was commonest (3 cases each).

Conclusions: Benign tumors were more common than malignant. The most common benign tumors were lipoma followed by hemangioma and schwannoma. The most common malignant tumor was pleomorphic sarcoma. The benign tumors were seen in younger age as compared to malignant tumors.


Keywords


Soft tissue tumors, Adipocytic tumors, Vascular tumors

Full Text:

PDF

References


Agravat AH, Dhruva GA, Parmar SA. Histopathology study of human's soft tissue tumours and tumour like lesions. J Cell Tissue Res. 2010;10(2):2287.

Enzinger FM, Weiss SW. Soft tissue tumors 2nd edition. St Louis, Mo: Mosby-Year Book. 1988;719-860.

Kumar V, Abbas AK, Fausto N, Mitchell R. Robbins basic pathology 8th edition. Saunders Elsevier. 2007;516-22.

Agarwal V, Greenebaum E, Wersto R. DNA ploidy of spindle cell soft- tissue tumors and its relationship to histology and clinical outcome. Arch Pathol Lab Med. 1991;115(6):558-62.

Harpal S, Richika R, Ramesh K. Histopathological pattern of soft tissue tumours in 200 cases. Ann Int Med Dent Res. 2016;2(6):6-11.

Singh HP, Grover S, Garg B, Sood N. Histopathological spectrum of soft-tissue tumors with immunohistochemistry correlation and FNCLCC grading: A North Indian Experience. Niger Med J. 2017;58(5):149.

Stevenson JT, Graham DJ, Khiyami A, Mansour EG. Squamous cell carcinoma of the breast: a clinical approach. Ann Surg Oncol. 1996;3(4):367-74.

Wibmer C, Leithner A, Zielonke N, Sperl M, Windhager R. Increasing incidence rates of soft tissue sarcomas? A population-based epidemiologic study and literature review. Ann Oncol. 2010;21(5):1106-11.

Trojani M, Contesso G, Coindre JM, Rouesse J, Bui NB, De Mascarel A, Goussot JF, David M, Bonichon F, Lagarde C. Soft‐tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer. 1984;33(1):37-42.

Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. Cancer J Clinicians. 2007;57(1):43-66.

Gustafson P. Epidemiology and clinical course in soft tissue sarcoma. Acta Orthopaedica. 1994;65:7-10.

Ducimetière F, Lurkin A, Ranchère-Vince D, Decouvelaere AV, Péoc'h M, Istier L, Chalabreysse P, Muller C, Alberti L, Bringuier PP, Scoazec JY. Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PloS One. 2011;6(8):e20294.

Makino Y. A clinicopathological study on soft tissue tumors of the head and neck. Pathol Int. 1979;29(3):389-408.

Kransdorf MJ. Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. AJR. Am J Roentgenol. 1995;164(2):395-402.

Fisher SB, Baxter KJ, Staley III CA, Fisher KE, Monson DK, Murray DR, Oskouei SV, Weiss SW, Kooby DA, Maithel SK, Delman KA. The General Surgeon's quandary: atypical lipomatous tumor vs lipoma, who needs a surgical oncologist? J Am Coll Surg. 2013;217(5):881-8.

Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG. A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg. 2005;102(2):246-55.