DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20212237

Clinical profile of tuberculosis with diabetes mellitus

Pooja Gautam, Neelima Sharma, Bishal Gautam, Preksha Sharma, Neha Sharma

Abstract


Background: There is now good evidence that people with diabetes mellitus (DM) have 2–3 times the risk of developing active tuberculosis (TB) compared with those who do not have DM. The aim of the study was to analyze typical / atypical presentation of pulmonary tuberculosis with diabetes mellitus.

Methods: This study was carried out in the Department of Respiratory Medicine and General Medicine, SAIMS, Indore during the period of July 2012 to June 2014. A prospective study including 100 microscopically proven cases of sputum smear positive pulmonary tuberculosis. Among these, 50 are diabetic patients with sputum positive tuberculosis and 50 are non-diabetic patients with sputum positive tuberculosis.

Results: The mean age in diabetic group was 51.92±9.96 years. The mean age in non-diabetic group was 39.58±15.19 years. In the diabetic group, there were 38 (76.00%) male and 12 (24.00%) females, while in the non-diabetic group there were 40 (80.00%) males and 10 (20.00%) females. Fever, cough and weakness were the three most common symptoms seen in patients with tuberculosis in both the groups.

Conclusions: There was a preponderance of male in both the groups over the female patients. There is no significant difference in the symptoms in both the groups.


Keywords


Tuberculosis, Diabetes mellitus, Immune suppression

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References


Ruslami R, Aarnoutse RE, Alisjahbana B. Implications of the global increase of diabetes for tuberculosis control and patient care. Trop Med Int Health. 2010;15(11):1289-99.

Webb EA, Hesseling AC, Schaaf HS, Gie RP, Lombard CJ, Spitaels A et al. High prevalence of mycobacterium tuberculosis infection and disease in children and adolescents with type 1 diabetes mellitus. Int J Tuberc Lung Dis. 2009;13(7):868-74.

Ottmani SE, Murray MB, Jeon CY, Baker MA, Kapur A, Lonnroth K et al. Consultation meeting on tuberculosis and diabetes mellitus: meeting summary and recommendations. Int J Tuberc Lung Dis. 2010;14(12):1513-7.

Stevenson C R, Critchley J A, Forouhi N G. Diabetes and the risk of tuberculosis: a neglected threat to public health. Chronic Illn. 2007;3:228-45.

Jeon C Y, Murray M B. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLOS Med. 2008;5:e152.

Baker M A, Harries A D, Jeon C Y. The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC Med. 2011;9:81.

Tatar D, Senol G, Alptekin S, Karakurum C, Aydin M, Coskunol I. Tuberculosis in Diabetics: Features in an Endemic Area. Jpn J Infect Dis. 2009;62(6):423-7.

Nissapatorn V, Kuppusamy I, Jamaiah I, Fong My, Rohela M, Anuar AK. Tuberculosis in diabetic patients A clinical perspective. Southeast Asian J Trop Med Public Health. 2005;36(Suppl 4):213-20.

Bacakoglu F, Basoglu OK, Cok G, Sayiner A, Ates M. Pulmonary tuberculosis in patients with diabetes mellitus. Respiration. 2001;68(6):595-600.

Deshmukh PA, Shaw T. Pulmonary tuberculosis and diabetes mellitus. Ind J Tub. 1984;31:114.

Tripathy SR, Kar KP, Chakraborthy DC, Majumdar AK. Diabetes mellitus and pulmonary tuberculosis – A prospective study. Ind J Tub. 1984;31:122.

Al-Wabel AH, Teklu B, Mahfouz AA, Al-Ghamdi AS, El-Amin OB, Khan AS. Symptomatology and chest roentgenographic changes of pulmonary tuberculosis among diabetics. East Afr Med. J.1997;74:62-4.

Nihalani KD, Menon P. Diabetes association with pulmonary tuberculosis. J Diabetes Assoc India. 1978;18:79.

Sachdeva AK, Arora RC, Misra DN. Clinicoradiological study of pulmonary tuberculosis in diabetics. J Assoc Physicians India. 1984;32:30.