DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20211903

SARS-CoV-2 specific antibody prevalence in health care personnel in a tertiary care teaching hospital treating COVID-19 patients

K. Padmapriya, Akshata Krishna Prabhu, Shincy Mettingal Ramakrishnan, Ravikumar Kadahalli Lingegowda, Sudhakar Honnamachanahalli

Abstract


Background: Serosurvey is a salient method for estimating infection rates and monitoring the progression of a pandemic. This study was done to determine the extent of seroprevalence of SARS-COV-2 antibodies among health care personnel of a tertiary care hospital.

Methods: Serum samples of 532 participants working in a teaching hospital which provides tertiary care services to the poor were tested for SARS-CoV-2-IgG antibodies. A questionnaire was used to collect demographic details and hygiene practices.

Results: 160 (30%) out of the 532 participants had IgG levels above the positive cut off value. The seroprevalence was higher in the nurses when compared to other class of staff working in the hospital.

Conclusions: The present study shows that the overall seroprevalence of SARS-CoV-2 in healthcare workers of a tertiary hospital in Bengaluru is high. This indicates that there is a need for the health care workers to take better precautions while treating COVID patients and emphasis should be given in training them to adhere to more stringent hygienic practices.


Keywords


COVID-19, IgG antibody, Health care personnel

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References


WHO. Fact sheet: Coronavirus disease (COVID-19) Dashboard, 2020. Available at: https://COVID19. who.int/. Accessed on 25 March 2021.

Worldometer. Fact sheet: COVID-19 coronavirus pandemic, 2020. Available at: https://www.worldo meters.info/coronavirus/country/india/. Accessed on 25 March 2021.

Hindustan Times. Fact sheet: India News, 2020. Available at: https://www.hindustantimes.com /india-news/COVID-19-cases-surge-top-10-cities-in-india-worst-hit-by-the-pandemic/story. Accessed on 25 March 2021.

Sotgiu G, Barassi A, Miozzo M, Saderi L, Piana A, Orfeo N, et al. SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital. BMC Pulmon Med. 2020;20:203.

Iversen K, Bundgaard H, Hasselbalchet RB, Kristensen JH, Nielsen PB, Pries-Heje M, et al. Risk of COVID-19 in health-care workers in Denmark: an observational cohort study. Lancet Infect Dis. 2020; 20(12):1401-8.

Rudberg A, Havervall S, MĂ„nberg A, Falk AJ, Aguilera K, Ng H, et al. SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden. Nat Commun. 2020;11(1):5064.

Pan Y, Li X, Yang G, Fan J, Tang Y, Hong X, et al. Seroprevalence of SARS-CoV-2 immunoglobulin antibodies in Wuhan, China: part of the city-wide massive testing campaign. Clin Microbiol Infect. 2021;27(2):253-7.

Venugopal U, Jilan N, Rabah S, Shariff MA, Jawed M, Batres AM, et al. SARS-CoV-2 seroprevalence among health care workers in a New York city hospital: a cross-sectional analysis during the COVID-19 pandemic. Int J Infect Dis. 2020:102(2021)63-9.

Murhekar MV, Bhatnagar T, Selvaraju S, Rade K, Saravanakumar V, Thangaraj JWV, et al. Prevalence of SARS-CoV-2 infection in India: Findings from the national serosurvey. Indian J Med Res. 2020;152(1-2):48-60.

The Hindu. Fact sheet: ICMR completes second serosurvey, 2020. Available at: https://www.the hindu.com/news/national/coronavirus-icmr-completes-second-sero-survey/article32654776.ece. Accessed on 25 March 2021.

Malani A, Shah D, Kang G, Lobo GN, Shastri J, Mohanan M, et al. Seroprevalence of SARS-CoV-2 in slums versus non-slums in Mumbai, India. Lancet Glob Health. 2020;9(2):110-1.

Babu GR, Sundaresan R, Athreya S, Akhtar J, Pandey PK, Maroor PS, et al. The burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population: Results from a statewide surveyin Karnataka, India. 2020.

Galanis P, Vraka I, Fragkou D, Bilali A, Kaitelidou D. Seroprevalence of SARS-CoV-2 antibodies and associated factors in health care workers: a systematic review and meta-analysis. J Hospital Infect. 2020;108:120-34.

Goenka M, Afzalpurkar S, Goenka U, Das SS, Mukherjee M, Jajodia S, et al. Seroprevalence of COVID-19 amongst health care workers in a tertiary care hospital of a metropolitan city from India. J Assoc Phys India. 2020;68(11):14-9.

Kumar A, Sathyapalan D, Ramachandran A, Subhash K, Biswas L, Beena KV. SARS-CoV-2 antibodies in healthcare workers in a large university hospital, Kerala, India. European Soc Clinic Microbiol Infect Dis. 2020;27(3):481-3.

Isho B, Abe KT, Zuo M, Jamal AJ, Rathod B, Wang JH, et al. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol. 2020;5(52):5511.

Centre for Disease Control and Prevention. Fact sheet: Seroprevalence of SARS-CoV-2 among frontline health care personnel in a multistate hospital network: 3 academics medical centers, morbidity and mortality weekly report, 2020 Available at: https://www.cdc.gov/mmwr. Accessed on 26 March 2021.

Bing. COVID-19 tracker, Karnataka, 2020. Available at: https://www.bing.com/COVID/local/ karnataka_india. Accessed on 26 March 2021.

Ministry of Health and Family Welfare. Fact sheet: Novel coronavirus disease 2019 (COVID-19): Guidelines on rational use of personal protective equipment. Available at: www.mohfwgovin/pdf/. Accessed on 26 March 2021.

Centers for Disease Control and Prevention. Fact sheet: Coronavirus disease 2019 (COVID-19): FAQ on hand hygiene recommendations, 2020. Available at: https://www.cdc.gov/coronavirus/2019-ncov/infection-control/hcp-hand-hygiene-faq.html. Accessed on 26 March 2021.