Amygdalin laetrile-a nascent vitamin B17: a review
DOI:
https://doi.org/10.18203/2320-6012.ijrms20212512Keywords:
Amygdalin, Antitumor, Beta-glucuronidase, Cyanogenic Toxicity, Laetrile, Rhodanese, Vitamin B17Abstract
Amygdalin is also called Vitamin B17 and its semi synthetic product is laetrile. It is a natural glycoside nutrient which gained popularity due to wide availability and low cost in treating various diseases. Vitamin B17 is derived from natural food sources and can be used for cancer prevention in alternative medicine practices. This review illustrates the proposed anticancer activity and other effects of amygdalin on different body systems along with a variety of clinical trials on humans and animals with pharmacological, toxicological effects and provides a perspective for further investigation and research.
References
Holzbecher MD, Moss MA, Ellenberger HA. The cyanide content of laetrile preparations, apricot, peach and apple seeds. J Toxicol Clin Toxico. 1984;22:341-7.
Do JS, Hwang JK, Seo HJ, Woo WH, Nam SY. Antiasthmatic activity and selective inhibition of type 2 helper T cell response by aqueous extract of semen armeniacae amarum. Immunopharmacol Immunotoxicol. 2006;28:213-25.
Hwang HJ, Lee HJ, Kim CJ, Shim I, Hahm DH. Inhibitory effect of amygdalin on lipopolysaccharide-inducible TNF-alpha and IL-1beta mRNA expression and carrageenan-induced rat arthritis. J Microbiol Biotechnol. 2008;18:1641-7.
Milazzo S, Horneber M. Laetrile treatment for cancer. Cochrane Database Syst Rev. 2015;(4):CD00547.
Contreras EJ. A new anticancer agent. InThe IX conference of the northwest medical confederation of the Mexican republic. 1980 (Vol. 15).
Liu C, Li X, Yang H, Mao X, Wang J, Gao W. Effect of Natural beta-Glucosidase Inhibitors in Reducing Toxicity of Amygdalin in Persicae Semen. Phytother Res. 2017;31(5):771–7.
Li X, Shi F, Zhang R, Sun C, Gong C, Jian L, Ding L. Pharmacokinetics, safety, and tolerability of amygdalin and paeoniflorin after single and multiple intravenous infusions of Huoxue-Tongluo lyophilized powder for injection in healthy Chinese volunteers. Clin Ther. 2016;38(2):327-37.
Navarro M. Letter to Andrew McNaughton, The McNaughton Foundation. Cancer News J. 1971:19-20.
Binzel PE. Alive and Well. California: American Media. 1994:21-23.
Griffin EG. World Without Cancer, The Story of Vitamin B17: Part one, Thousand Oaks, CA: American Media; 1974.
Dorr RT, Paxinos J. The current status of laetrile. Ann Intern Med. 1978;89:389-97.
Curran WJ. Law-medicine notes. Laetrile for the terminally ill: Supreme Court stops the nonsense. N Engl J Med. 1980;302(11):619-21.
Qadir M, Fatima K. Review on Pharmacological Activity of Amygdalin. Archives in Cancer Research. 2017;5(4):160.
Holzbecher MD, Moss MA, Ellenberger HA. The cyanide content of laetrile preparations, apricot, peach and apple seeds. J Toxicol Clin Toxico. 1984;22:341-7.
Story of vitamin B-17. Available from: http://healthandsciences.blogspot.com/2015/11/story-of-amygdalinlaetrileb17-and-cancer.html. Accessed at 20 Jan, 2020.
Chittranjan NN, Shinde R. Methods of extraction. Text book of Medical Biochemistry,8th Edition.
Hydrolysis reaction of amygdalin. Available from: http://www.chm.bris.ac.uk/motm/amygdalin/amygdalinh.html. Accessed at 20 Jan, 2020.
Manner HW, Michaelson TL, DiSanti SJ. Enzymatic Analysis of Normal and Malignant Tissues, Presented at the Illinois State Academy of Science; 1978.
Yun-long Li, Qiao-xing Li, Rui-jiang Liu, Xiang-qian Shen. Chinese medicine Amygdalin and β-glucosidase combined with antibody enzymatic prodrug system as a feasible antitumor therapy. Chin J Integr Med. 2018;24(3):237-40.
Healing Cancer with Alternative Method. Laetrile. Available from: https://cancercompassalternateroute.com/therapies/vitamin-b17-laetrile/. Accessed at 20 Jan, 2020.
Do JS, Hwang JK, Seo HJ, Woo WH, Nam SY. Antiasthmatic activity and selective inhibition of type 2 helper T cell response by aqueous extract of semen armeniacae amarum. Immunopharmacol Immunotoxicol. 2006;28:213-25.
Guo J, Wu W, Sheng M, Yang S, Tan J. Amygdalin inhibits renal fibrosis in chronic kidney disease. Molecular Medicine Reports. 2013;7:1453-7.
Perez JJ. Amygdalin analogs for the treatment of psoriasis. Future Med Chem. 2013;5:799-808.
Shim SM, Kwon H. Metabolites of amygdalin under simulated human digestive fluids. Int J Food Sci Nutr. 2010;61:770-9.
Zhu YP, Su ZW, Li CH. Analgesic effect and no physical dependence of amygdalin. Zhongguo Zhong Yao Za Zhi China J Chinese Materia Medica. 1994;19:105-7.
Heikkila RE, Cabbat FS. The prevention of alloxan-induced diabetes by amygdalin. Life sci. 1980;27:659-62.
Chen Y, Ma J, Wang F, Hu J, Cui A, et al. Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells. Immunopharmacol Immunotoxicol. 2013;35:43-51.
Fukuda T, Ito H, Mukainaka T, Tokuda H, Nishino H, et al. Anti-tumor promoting effect of glycosides from Prunus persica seeds. Biol Pharm Bull. 2003;26:271-3.
Qian L, Xie B, Wang Y, Qian J. Amygdalin‐mediated inhibition of non‐small cell lung cancer cell invasion in vitro. Int J Clin Exp Pathol. 2015;8(5):5363‐70.
Makarević J, Rutz J, Juengel E, Kaulfuss S, Tsaur I, Nelson K, et al. Amygdalin influences bladder cancer cell adhesion and invasion in vitro. PLoS ONE. 2014;9(10): e110244.
Juengel E, Thomas A, Rutz J, Makarevic J, Tsaur I, Nelson K, et al. Amygdalin inhibits the growth of renal cell carcinoma cells in vitro. Int J Mol Med.2016;37(2):526‐532.
Chen YU, Ma J, Wang F, Hu J, Cui A, Wei C, et al. Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells. Immunopharmacol Immunotoxicol. 2013;35(1):43‐51.
Hye Min Lee, Aree Moon. Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cell .Biomol Ther. 2016;24(1):62-6.
Moon A, Kim MS, Kim TG, Kim SH, Kim HE, Chen YQ, et al. H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: a role for MMP-2 in the H-ras-induced invasive phenotype. Int J Cancer. 2000;85:176-81.
Vellon L, Menendez JA, Lupu R. A bidirectional "alpha(v) beta (3) integrin-ERK1/ERK2 MAPK" connection regulates the proliferation of breast cancer cells. Mol. Carcinog. 2006;45:795-804.
Makarević J, Tsaur I, Juengel E, Borgmann H, Nelson K, Thomas C, et al. Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro. Life Sci. 2016;147:137-42.
Park HJ, Yoon SH, Han LS, Zheng LT, Jung KH, Uhm YK, et al. Amygdalin inhibits genes related to cell cycle in SNU‐C4 human colon cancer cells. World J Gastroenterol. 2005;11(33):5156‐61.
Ji-Yoon Moon, Sang-Won Kim, Gi-Mok Yun, Hyeon-Sik Lee, Yoon-Dong Kim, Gie-Joon Jeong,et al. Inhibition of cell growth and down-regulation of telomerase activity by amygdalin in human cancer cell lines. Animal Cells Syst. 2015;19(5):295-304.
Halenár M, Medvedová M, Maruniaková N, Kolesárová A. Ovarian hormone production affected by amygdalin addition in vitro. J Microbiol Biotech Food Sci. 2015;4(special issue 2):19-22.
Adewusi SR, Oke OL. On the metabolism of amygdalin .The LD50 and biochemical changes in rats. Can J Physiol Pharmacol. 1985;63:1080‑3.
Committee on Toxicity (COT). Statement on cyanogenıc glycosides in bitter apricot kernels. committee on toxicity of chemicals in food, consumer products and the environment [Online] 2006. Available at https://cot.food.gov.uk/. Accessed at 20 Jan, 2020.
Taylor J. Toxicological profile for cyanide. US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry; 2006.
Bradford R, Culbert M, Allen H. International Protocols for Individualized, Integrated Metabolic Programs in Cancer Management. Los Altos, CA: The Robert W. Bradford Foundation; 1983.
Suchars J, Wallace K, Gerkin R. Acute cyanide toxicity caused by apricot ingestion. Ann Emerg Med. 1988;32(6):742-4.
O’Brien B, Quigg C, Leong T. Severe cyanide toxicity from ‘vitamin supplements’. Eur J Emerg Med. 2005;12(5):257.
Sauer H, Wollny C, Oster I, Tutdibi E, Gortner L, Gottschling S, et al. Severe cyanide poisoning from an alternative medicine treatment with amygdalin and apricot kernels in a 4-year-old child. Wiener Medizinische Wochenschrift. 2015;165(9):185-8.
Ellison N, Bvar D, Newell G. Special report on Laetrile: The NCI Laetrile Review N Engl J Med. 1978;299(10):549-52.
Moss R. The Cancer Industry. Brooklyn: Equinox Press. 3rd ed; 1966.
Griffin E. World Without Cancer: The Story of VitaminB-17. Westlake Village, CA: American Media. 2nd ed; 1997.
Krashen D. Inaccurate reporting of the effects of Laetrile: Mistreatment of Ellison, Byar and Newell in professional papers. Internet J Altern Med. 2009;6(2).
Yang HY, Chang HK, Lee JW, Kim YS, Kim H, Lee MH, et al. Amygdalin suppresses lipopolysaccahride-induced expressions of cyclooxygenase-¬2 and inducible nitric oxide synthase in mouse BV2 microglial cells. Neurol Res. 2007;29(6):59-64.
Hall AH, Christopher HL, Kenneth WK, Rumack BH. Cyanide Poisoning from Laetrile Ingestion: Role of Nitrile Therapy. Pediatrics. 1986;78(2):289-72.
Enculescu M. Vitamin B17/Laetrile/Amygdalin (a Review): Bulletin UASVM Animal Science and Biotechnologies; 2009.
