Clinicopathological characteristics of colon cancers in a tertiary care centre

Authors

  • C. Deepak Yadlapalli Department of Medical Oncology, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India
  • Kovvuri Hari Lalith Reddy Department of General Medicine, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India
  • Yerraguntla S. Sarma Department of Medical Oncology, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India
  • Samir Ranjan Nayak Department of General Surgery, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India
  • Gogineni Tarun Chowdary Department of Surgical Oncology, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India
  • Muralidhar Gullipalli Department of Medical Oncology, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India
  • Venkatesh Mushini Department of Medical Oncology, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20212529

Keywords:

Colon cancer, India, Aarogyasri program

Abstract

Background: Colon cancer is a leading cause of increase in cancer incidence and now becoming a major cause of cancer related mortality.

Methods: We evaluated data of patients diagnosed with colon cancer and managed under Aarogyasri program between 2013 and 2019 at a tertiary care cancer hospital in Rajamahenderi, Andhra Pradesh, India. We collected data regarding demography, clinical presentation, subsite, histology, stage and treatment.

Results: A total of 142 patients with colon cancer were managed. The mean age was 53.6 years with males accounting for 57%. Most common clinical presentation was abdominal pain followed by vomiting. Most common histology was well differentiated adenocarcinoma. Left sided colon tumors accounted for 47%. Most common stage at presentation was stage III.

Conclusions: Our data of colon cancer was different from that described in the western countries. Young age presentation, higher mucinous and signet ring carcinomas and advanced stage presentation were reported in our study. Socioeconomic factors, inadequate health care access might account for some of these differences.

Author Biographies

Kovvuri Hari Lalith Reddy, Department of General Medicine, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India

Junior Resident, General Medicine

Yerraguntla S. Sarma, Department of Medical Oncology, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India

Professor, Medical Oncology

Samir Ranjan Nayak, Department of General Surgery, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India

Professor, General Surgery

References

WHO. Fact sheet: Global Health Observatory: Geneva, 2018. Available at: who.int/gho/database/en/. Accessed on 15 May 2021.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.

Bray F. Transitions in human development and the global cancer burden. In: Stewart BW, Wild CP, eds. World Cancer Report 2014. Lyon: IARC Press; 2014: 42-55.

Liu Z, Zhang Y, Niu Y, Li K, Liu X, Chen H, et al. A systematic review and meta-analysis of diagnostic and prognostic serum biomarkers of colorectal cancer. PLoS One. 2014;9(8):103910.

Magalhaes B, Peleteiro B, Lunet N. Dietary patterns and colorectal cancer: systematic review and meta-analysis. Eur J Cancer Prev. 2012;21(1):15-23.

WHO. Fact sheet: Global Cancer Observatory. Available at: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx. Accessed on 15 May 2021.

Sarkar S, Mukherjee R, Paira SK, Roy B, Banerjee S, Mukherjee SK. Profile of colorectal cancer in Eastern India. J Indian Med Assoc. 2012;110(12):901-3.

Bae JM, Jung KW, Won YJ. Estimation of cancer deaths in Korea for the upcoming years. J Korean Med Sci. 2002;17(5):611-5.

Tamura K, Ishiguro S, Munakata A, Yoshida Y, Nakaji S, Sugawara K. Annual changes in colorectal carcinoma incidence in Japan. Analysis of survey data on incidence in Aomori Prefecture. Cancer. 1996;78(6):1187-94.

Ahuja N, Chang D, Gearhart SL. Disparities in colon cancer presentation and in-hospital mortality in Maryland: a ten-year review. Ann Surg Oncol. 2007;14(2):411-6.

Deo SV, Shukla NK, Srinivas G, Mohanti BK, Raina V, Sharma A, et al. Colorectal cancers– experience at a regional cancer centre in India. Trop Gastroenterol. 2001;22(2):83-6.

Edwards BK, Noone A, Mariotto AB, Simard EP, Boscoe FP, Henley SJ, et al. Annual report to the nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer. 2014;120(9):1290-314.

Davis DM, Marcet JE, Frattini JC, Prather AD, Mateka JJL, Nfonsam VN. Is it time to lower the recommended screening age for colorectal cancer? J Am Coll Surg. 2011;213(3):352-61.

Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin. 2014;64(2):104-17.

Badwe RA, Dikshit R, Laversanne M, Bray F. Cancer incidence trends in India. Jpn J Clin Oncol. 2014;44(5):401-7.

BSRS: chapter-2 population composition. Available at: http://www.censusindia.gov.in/vital_statistics/ srs_report/9chap2-2011.pdf. Accessed on 25 October 2016.

IRIS Knowledge Foundation. Fact sheet: State of the urban youth, India 2012. Available at: http://www.esocialsciences.org/general/a201341118517_19.pdf. Accessed on 15 May 2021.

Suryadevara S, Veerendra KKV, Pampanagouda SKM, Arjun R, Deshmani V. Colorectal cancer profile in a tertiary care centre, Bangalore, India. Online J Heal allied Sci. 2014;13(1):1-4.

Majumdar SR, Fletcher RH, Evans AT. How does colorectal cancer present? Symptoms, duration, and clues to location. Am J Gastroenterol. 1999;94(10):3039-45.

Sinha R, Doval DC, Hussain S, Kumar K, Singh S, Basir SF, et al. Lifestyle and sporadic colorectal cancer in India. Asian Pac J Cancer Prev. 2015;16(17):7683-8.

Mohandas KM, Desai DC. Epidemiology of digestive tract cancers in India. V. Large and small bowel. 1999) Epidemiology of digestive tract cancers in India. V. Large and small bowel. Indian J Gastroenterol. 1999;18(3):118-21.

Locker GY, Hamilton S, Harris J, Jessup JM, Kemeny N, Macdonald JS, et al. ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol. 2006;24(33):5313-27.

Nitsche U, Zimmermann A, Späth C, Müller T, Maak M, Schuster T, et al. Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis. Ann Surg. 2013;258(5):775-83.

Hyngstrom JR, Hu C, Xing Y, You YN, Feig BW, Skibber JM, et al. Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma: analysis from the National Cancer Data Base. Ann Surg Oncol. 2012;19(9):2814-21.

Siegel RL, Miller KD, Jemal A. Cancer statistics. CA Cancer J Clin. 2016;66(1):7-30.

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Published

2021-06-25

How to Cite

Yadlapalli, C. D., Lalith Reddy, K. H., Sarma, Y. S., Nayak, S. R., Chowdary, G. T., Gullipalli, M., & Mushini, V. (2021). Clinicopathological characteristics of colon cancers in a tertiary care centre. International Journal of Research in Medical Sciences, 9(7), 2062–2066. https://doi.org/10.18203/2320-6012.ijrms20212529

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Original Research Articles