DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20212505

A study of atherogenic index of plasma in myocardial infarction patients admitted in Silchar medical college, Assam, India

Biswadeep Choudhury, Manidip Chakraborty, Nabiha Mayanaz Karim

Abstract


Background:It is an established fact that dyslipidemia is one of the major risk factors for cardiovascular diseases like myocardial infarction. Major well-known alterations in lipid profile include high serum cholesterol, low density lipoprotein cholesterol (LDL-C), triglyceride and low high density lipoprotein cholesterol (HDL-C). Recently, it has been found that atherogenic index of plasma (AIP); which is a logarithmically transformed ratio of triglyceride and HDL-C; can predict cardio-vascular disease risk and can also be used for cardio-vascular disease risk stratification. In this study we have calculated the AIP from fasting lipid profile of patients suffering from myocardial infarction and tried to assess the correlation between AIP and myocardial infarction.

Methods: The study comprised of fifty patients suffering from myocardial infarction aged more than 18 with no prior history of cardiovascular diseases. We measured fasting lipid profile using Vitros 5600 full auto analyzer and calculated AIP using online AIP calculator. Statistical analysis was done using “Microsoft excel 2019” with add on. A significant percentage (66%) of myocardial infarction patients had higher AIP (>0.21) and fell in the high-risk group. We also got a significant relationship between AIP-triglyceride and AIP-HDL-C (p<0.05 considered as statistically significant).

Conclusions: AIP is high in myocardial infarction patients. In this group, besides high AIP, they also have low HDL-C and high triglycerides which are significant. So, AIP can be used as a tool for cardio-vascular disease risk stratification.


Keywords


AIP, Myocardial infarction, Triglyceride, High density lipoprotein

Full Text:

PDF

References


Ghosh T. Hand book of lipidology, 1st ed. Jaypee brothers. 2016:1-2.

Ghuge G, Zine R. Atherogenic index of plasma in myocardial infarction in rural population of Marathwada region. J Evolution Med Dental Sci. 2012;1(3):28;237-40.

Lafta MA. A comparative study for some atherogenic indices in sera of myocardial infarction, ischemic heart disease patients and control. J Natural Sci Res. 2014;4(8):96-102.

Mahfouz RA. Utility of atherogenic index of plasma in predicting plaque burden in patients with chest pain and intermediate pretest probability of coronary artery disease: J Clin Exp Cardiolog. 2018;9:8.

Ilhamifithri I, Yaswir R, Alia E, Efrida E. Correlation of atherogenic index of plasma with stenosis level of coronary artery in acute coronary syndrome. Indonesian J clin pathol med lab. 2018;25(1):1-128.

Rismawati Y, Efrida E, Muhammad F. The correlation of atherogenic index of plasma and small dense low-density lipoprotein with the degree of coronary artery stenosis in acute coronary syndrome: ICOMHER. 2018;13-4.

Dobiasova M. Atherogenic impact of lecithin-cholesterol acyltransferase and its relation to cholesterol esterification rate in HDL (FERHDL) and AIP [log (TG/HDL-C)] biomarkers: The butterfly effect? Physiol Res. 2017;66(2):193-203.

Cardiovascular Diseases. World Health Organization. Available at: www.who.int/health-topics/cardiovascular-diseases/a. Accessed on 26/2/2021.

SuBo M, Cheah WL, Lwin S, New TM, Win TT, Aung M. Understanding the relationship between atherogenic index of plasma and cardiovascular disease risk factors among staff of a university in Malaysia. Hindawi J Nutri Metabolism. 2018;7027624.

Cai G, Shi G, Xue S, Lu W. The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population. Medicine. 2017;96(37):e8058.

Kazemi T. Cardiovascular risk factor and atherogenic indices in an Iranian population: Birjand East of Iran. 2018.

Guo Q. The sensibility of the new blood lipid indicator-atherogenic index of plasma (AIP) in menopausal women with coronary artery disease. Lipids Health Dis. 2020;19:27.